Broad-spectrum antiviral properties of andrographolide
- 28 November 2016
- journal article
- review article
- Published by Springer Science and Business Media LLC in Archiv für die gesamte Virusforschung
- Vol. 162 (3), 611-623
- https://doi.org/10.1007/s00705-016-3166-3
Abstract
Andrographolide, a diterpenoid, is known for its anti-inflammatory effects. It can be isolated from various plants of the genus Andrographis, commonly known as ‘creat’. This purified compound has been tested for its anti-inflammatory effects in various stressful conditions, such as ischemia, pyrogenesis, arthritis, hepatic or neural toxicity, carcinoma, and oxidative stress, Apart from its anti-inflammatory effects, andrographolide also exhibits immunomodulatory effects by effectively enhancing cytotoxic T cells, natural killer (NK) cells, phagocytosis, and antibody-dependent cell-mediated cytotoxicity (ADCC). All these properties of andrographolide form the foundation for the use of this miraculous compound to restrain virus replication and virus-induced pathogenesis. The present article covers antiviral properties of andrographolide in variety of viral infections, with the hope of developing of a new highly potent antiviral drug with multiple effects.Keywords
Funding Information
- Defence Research and Development Organisation (Sub Project)
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