Comprehensive analysis of MHC‐II expression in healthy human skin
- 6 March 2007
- journal article
- Published by Wiley in Immunology & Cell Biology
- Vol. 85 (5), 363-369
- https://doi.org/10.1038/sj.icb.7100047
Abstract
A number of antigen‐presenting cells (APCs) expressing major histocompatibility complex class II (MHC‐II) have been identified in healthy human skin including the Langerhans cells of the epidermis and the three recently defined dermal APC subsets. It is well documented that in other tissues HLA‐DR expression is not exclusive to APCs. Following a comprehensive analysis of the cells in human skin using flow cytometry and fluorescence immunohistochemistry, we have identified additional cell subsets that express HLA‐DR. Using markers exclusive for blood and lymphatic endothelium, we demonstrated that both of these cell populations have the capacity to express HLA‐DR. In addition, a small subset of dermal T lymphocytes was found to express low‐level HLA‐DR suggesting an activated phenotype. Dermal T lymphocytes were often in intimate contact with either CD1a+ CD207− dermal APCs or CD1a+ CD207+ dermal Langerhans cells, possibly explaining the activated phenotype of a subset of dermal T lymphocytes.Keywords
Funding Information
- Wellcome Trust
This publication has 34 references indexed in Scilit:
- Langerhans Cells Activate Naive Self-Antigen-Specific CD8 T Cells in the Steady StateImmunity, 2004
- Expression of C‐type lectin receptors by subsets of dendritic cells in human skinInternational Immunology, 2004
- Function and regulation of MHC class II molecules in T-lymphocytes: of mice and menHuman Immunology, 2004
- Diversity of receptors binding HIV on dendritic cell subsetsNature Immunology, 2002
- Tracking T cells with tetramers: new tales from new toolsNature Reviews Immunology, 2002
- Professional presentation of antigen by activated human T cellsEuropean Journal of Immunology, 1994
- Human T cells cannot act as autonomous antigen-presenting cells, but induce tolerance in antigen-specific and alloreactive responder cells.The Journal of Experimental Medicine, 1992
- Early signaling defects in human T cells anergized by T cell presentation of autoantigen.The Journal of Experimental Medicine, 1992
- Cultured Human Langerhans Cells Resemble Lymphoid Dendritic Cells in Phenotype and FunctionJournal of Investigative Dermatology, 1989
- A human suppressor T cell clone which recognizes an autologous helper T cell cloneNature, 1982