Expression of CXCL13 by Neoplastic Cells in Angioimmunoblastic T-Cell Lymphoma (AITL)
- 1 April 2006
- journal article
- Published by Ovid Technologies (Wolters Kluwer Health) in The American Journal of Surgical Pathology
- Vol. 30 (4), 490-494
- https://doi.org/10.1097/00000478-200604000-00009
Abstract
Angioimmunoblastic T-cell lymphoma (AITL) represents a distinct entity among peripheral T-cell lymphomas (PTCLs). The cellular origin of AITL remains unknown, although a possible derivation from follicular helper T cells (TFH) has been suggested based on the CD4/Bcl-6 phenotype. It has been recently shown that expression of CXCL13, a chemokine critically involved in B-cell migration into germinal centers, is characteristic of TFH cells, as compared with other T helper subsets. We compared CXCL13 expression in 29 AITLs, 20 PTCLs, unspecified, 10 anaplastic large cell lymphomas (ALCL), and 4 other PTCLs. We showed that CXCL13 is expressed by AITL (29 of 29, 100%) and a subset of PTCL, unspecified (6 of 20, 30%), which all showed borderline features with AITL, but in only 1 of 10 (10%) ALCLs, and 0 of 4 other PTCLs. Two-color immunostainings further showed that CXCL13 was found in the cytoplasm of atypical CD5-positive T cells that expressed CD10. We conclude that CXCL13 expression is a common characteristic of AITL, which can help to delineate the morphologic spectrum of the disease, and further supports its derivation from TFH cells. CXCL13 expression may also provide an additional useful tool for the diagnosis of AITL.This publication has 26 references indexed in Scilit:
- Balanced expression of CXCR5 and CCR7 on follicular T helper cells determines their transient positioning to lymph node follicles and is essential for efficient B-cell helpBlood, 2005
- Angioimmunoblastic T-cell lymphoma: a neoplasm of germinal-center T-helper cells?Blood, 2005
- T Follicular Helper Cells Express a Distinctive Transcriptional Profile, Reflecting Their Role as Non-Th1/Th2 Effector Cells That Provide Help for B CellsThe Journal of Immunology, 2004
- Benign CD10-Positive T Cells in Reactive Lymphoid Proliferations and B-Cell LymphomasLaboratory Investigation, 2003
- Angioimmunoblastic T‐cell lymphomaBritish Journal of Haematology, 2003
- CD69 expression correlates with expression of other markers of Th1 T cell differentiation in peripheral T cell lymphomasHuman Pathology, 2002
- Neoplastic T cells in angioimmunoblastic T-cell lymphoma express CD10Blood, 2002
- Follicular B Helper T Cells Express Cxc Chemokine Receptor 5, Localize to B Cell Follicles, and Support Immunoglobulin ProductionThe Journal of Experimental Medicine, 2000
- A chemokine-driven positive feedback loop organizes lymphoid folliclesNature, 2000
- Visualization of Specific B and T Lymphocyte Interactions in the Lymph NodeScience, 1998