VIOLATIONS OF HOMEOSTASIS PARAMETERS IN ACUTE POISONINGS AND WAYS OF THEIR CORRECTION

Abstract

N.V. Sklifosovsky Research Institute for Emergency Medicine, Healthcare Department of Moscow|, 129090, Moscow, Russian Federation Research and Applied Toxicology Center of Federal Medical and Biological Agency|, 129090, Moscow, Russian Federation Russian Medical Academy of Continuous Professional Education, RF Ministry of Health|, 125993, Moscow, Russian Federation The problem of correction of disturbed homeostasis parameters in critical conditions, including acute poisoning, has revealed its increasing importance in recent years. In this respect, extracorporeal methods of detoxification (hemosorption, hemodialysis, etc.) and physio- and chemohemotherapy are quite effective. With the help of these methods positive changes in hemorheological, immune and other parameters are achieved, that increase significantly the overall results of treatment of patients. At the same time, targeted correction of disturbed homeostasis outside detoxification activities is still carried out mainly through infusion therapy. Along with this in recent years a growing number of scientific papers devoted to the correction of homeostatic disorders by enteral administration of special solutions in emergency conditions has appeared. However, this approach, although physiological and technically simple, has not yet been studied in clinical toxicology, and this fact encourages further research in this direction.