From Atoxyl to Salvarsan: Searching for the Magic Bullet
- 1 August 2005
- journal article
- other
- Published by S. Karger AG in Chemotherapy
- Vol. 51 (5), 234-242
- https://doi.org/10.1159/000087453
Abstract
March 15th of 2004 marked the 150th anniversary of the birth of Paul Ehrlich. He was the founder of modern chemotherapy and in fact coined the word and invented the science of chemical therapy. He and his chemist Al fred Bertheim were the first people to do three things: (1) identify a substance, either man-made or from natural products, which showed promise in killing certain invading organisms; (2) determine the correct structure of the active compound in this substance, and (3) modify the chemical structure of this compound to make it more potent to invading organisms and less harmful to the host.Keywords
This publication has 11 references indexed in Scilit:
- The Return of Ehrlich’s ‘Therapia magna sterilisans’ and Other Ehrlich Concepts?Chemotherapy, 2004
- World Conference on Dosing of Antiinfectives:‘Dosing the Magic Bullets’Chemotherapy, 2004
- Form and Function: Early Efforts to Relate Chemical Structure and Pharmacological ActivityCanadian Journal of Health History, 1988
- The structure of salvarsan and the arsenic-arsenic double bondJournal of Chemical Education, 1977
- Chemotherapy: history and principlesPublished by Springer Science and Business Media LLC ,1973
- Paul EhrlichPublished by Springer Science and Business Media LLC ,1951
- Über p‐AminophenylarsinsäureEuropean Journal of Inorganic Chemistry, 1907
- SOME EXPERIMENTS IN THE TREATMENT OF TRYPANOSOMIASISBMJ, 1905
- Untersuchungen über die KakodylreiheEuropean Journal of Organic Chemistry, 1843
- Untersuchungen über die KakodylreiheEuropean Journal of Organic Chemistry, 1842