Conventional inactivated bivalent H5/H7 vaccine prevents viral localization in muscles of turkeys infected experimentally with low pathogenic avian influenza and highly pathogenic avian influenza H7N1 isolates
- 14 July 2008
- journal article
- Published by Informa UK Limited in Avian Pathology
- Vol. 37 (4), 407-412
- https://doi.org/10.1080/03079450802061124
Abstract
International audienceHighly Pathogenic Avian Influenza (HPAI) viruses cause viraemia and systemic infections with virus replication in internal organs and muscles, in contrast Low Pathogenicity Avian Influenza (LPAI) viruses produce mild infections with low mortality rates and local virus replication. There is little available information on the ability of LPAI viruses to cause viraemia or on the presence of AI viruses in general in the muscles of infected turkeys. The aim of this study was to determine the ability of LPAI and HPAI H7N1 viruses to reach muscle tissues following experimental infection and the efficacy of vaccination in preventing viraemia and meat localisation. The potential of infective muscle tissue to act as a source of infection for susceptible turkeys by mimicking the practice of swill-feeding was also investigated. The HPAI virus was isolated from blood and muscle tissues of all unvaccinated turkeys, LPAI could be isolated only from blood of one bird and could be detected only by RT-PCR in muscles. In contrast, in vaccinated/challenged turkeys, no viable virus or viral RNA could be detected in muscles indicating that in vaccinated birds viral localisation in muscle tissue is preventedKeywords
This publication has 19 references indexed in Scilit:
- A conventional, inactivated oil emulsion vaccine suppresses shedding and prevents viral meat colonisation in commercial (Pekin) ducks challenged with HPAI H5N1Vaccine, 2007
- Emerging microbiological food safety issues related to meatMeat Science, 2006
- Experimental Study to Determine if Low-Pathogenicity and High-Pathogenicity Avian Influenza Viruses Can Be Present in Chicken Breast and Thigh Meat Following Intranasal Virus InoculationAvian Diseases, 2005
- Co-infection of Staphylococcus aureus or Haemophilus paragallinarum exacerbates H9N2 influenza A virus infection in chickensArchiv für die gesamte Virusforschung, 2004
- Comparative Susceptibility of Chickens and Turkeys to Avian Influenza A H7N2 Virus Infection and Protective Efficacy of a Commercial Avian Influenza H7N2 Virus VaccineAvian Diseases, 2004
- Evaluation of a High-Pathogenicity H5N1 Avian Influenza A Virus Isolated from Duck MeatAvian Diseases, 2003
- Detection of H7 Avian Influenza Virus Directly from Poultry SpecimensAvian Diseases, 2003
- Development of a DIVA (Differentiating Infected from Vaccinated Animals) strategy using a vaccine containing a heterologous neuraminidase for the control of avian influenzaAvian Pathology, 2003
- Characterization of a Highly Pathogenic H5N1 Avian Influenza A Virus Isolated from Duck MeatJournal of Virology, 2002
- The avian influenza epidemic in Italy, 1999—2000: A reviewAvian Pathology, 2000