Extended Y Chromosome Investigation Suggests Postglacial Migrations of Modern Humans into East Asia via the Northern Route
Open Access
- 13 September 2010
- journal article
- research article
- Published by Oxford University Press (OUP) in Molecular Biology and Evolution
- Vol. 28 (1), 717-727
- https://doi.org/10.1093/molbev/msq247
Abstract
Genetic diversity data, from Y chromosome and mitochondrial DNA as well as recent genome-wide autosomal single nucleotide polymorphisms, suggested that mainland Southeast Asia was the major geographic source of East Asian populations. However, these studies also detected Central–South Asia (CSA)- and/or West Eurasia (WE)-related genetic components in East Asia, implying either recent population admixture or ancient migrations via the proposed northern route. To trace the time period and geographic source of these CSA- and WE-related genetic components, we sampled 3,826 males (116 populations from China and 1 population from North Korea) and performed high-resolution genotyping according to the well-resolved Y chromosome phylogeny. Our data, in combination with the published East Asian Y-haplogroup data, show that there are four dominant haplogroups (accounting for 92.87% of the East Asian Y chromosomes), O-M175, D-M174, C-M130 (not including C5-M356), and N-M231, in both southern and northern East Asian populations, which is consistent with the proposed southern route of modern human origin in East Asia. However, there are other haplogroups (6.79% in total) (E-SRY4064, C5-M356, G-M201, H-M69, I-M170, J-P209, L-M20, Q-M242, R-M207, and T-M70) detected primarily in northern East Asian populations and were identified as Central-South Asian and/or West Eurasian origin based on the phylogeographic analysis. In particular, evidence of geographic distribution and Y chromosome short tandem repeat (Y-STR) diversity indicates that haplogroup Q-M242 (the ancestral haplogroup of the native American-specific haplogroup Q1a3a-M3) and R-M207 probably migrated into East Asia via the northern route. The age estimation of Y-STR variation within haplogroups suggests the existence of postglacial (∼18 Ka) migrations via the northern route as well as recent (∼3 Ka) population admixture. We propose that although the Paleolithic migrations via the southern route played a major role in modern human settlement in East Asia, there are ancient contributions, though limited, from WE, which partly explain the genetic divergence between current southern and northern East Asian populations.Keywords
This publication has 63 references indexed in Scilit:
- A Predominantly Neolithic Origin for European Paternal LineagesPLoS Biology, 2010
- Mapping Human Genetic Diversity in AsiaScience, 2009
- Two Sources of the Russian Patrilineal Heritage in Their Eurasian ContextAmerican Journal of Human Genetics, 2008
- Phylogeographic Analysis of Mitochondrial DNA in Northern Asian PopulationsAmerican Journal of Human Genetics, 2007
- Y chromosome genetic variation in the Italian peninsula is clinal and supports an admixture model for the Mesolithic–Neolithic encounterMolecular Phylogenetics and Evolution, 2007
- Paternal and maternal lineages in the Balkans show a homogeneous landscape over linguistic barriers, except for the isolated AromunsAnnals of Human Genetics, 2006
- Excavating Y-chromosome haplotype strata in AnatoliaHuman Genetics, 2004
- Y-Chromosome Evidence for Differing Ancient Demographic Histories in the AmericasAmerican Journal of Human Genetics, 2003
- A novel multiplex for simultaneous amplification of 20 Y chromosome STR markersForensic Science International, 2002
- Median-joining networks for inferring intraspecific phylogeniesMolecular Biology and Evolution, 1999