Ring-based analogues of pentamidine versus P. carinii pneumonia in culture
- 1 October 1996
- journal article
- Published by Elsevier BV in Bioorganic & Medicinal Chemistry Letters
- Vol. 6 (19), 2367-2370
- https://doi.org/10.1016/0960-894x(96)00427-1
Abstract
The synthesis of aromatic ring-based pentamidine analogues, in which the aliphatic bridge has been replaced by benzene, pyridine, or pyrimidine has been accomplished in two steps. Compounds containing benzene and pyridine as the central core of the molecule have demonstrated activity against PCP in culture.Keywords
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