Mass producible and biocompatible microneedle patch and functional verification of its usefulness for transdermal drug delivery
- 16 July 2009
- journal article
- Published by Springer Science and Business Media LLC in Biomedical Microdevices
- Vol. 11 (6), 1195-1203
- https://doi.org/10.1007/s10544-009-9337-1
Abstract
The key issues in the development of a microneedle patch as a tool for transdermal drug delivery are safety and delivery performance in addition to economical production. In this paper, novel fabrication methods for an inexpensive microneedle patch made of biocompatible polymer are reported, along with functional verifications for the fabricated microneedle patch through animal models. We combined the merits of in-line microneedles, i.e., easy and economical production, with the superior performance of two-dimensionally arrayed microneedles. One-dimensionally fabricated microneedles were assembled to make two-dimensionally arrayed patches to attain our goal. First, we fabricated strips with one-dimensionally arrayed microneedles through deep X-ray lithography on polymethylmethacrylate or another negative photoresist, SU-8, with sharply reduced exposure time. Second, we assembled microneedle strips to make two-dimensionally arrayed microneedles, which we utilized further for fabrication of molding masters. Finally, we prepared microneedle patches made of polycarbonate by hot embossing with these masters. We then demonstrated the actual delivery of exogenous materials through application on skin via animal experiments, and we found no detectable side effects such as inflammation or allergic reactions at the site of application.Keywords
This publication has 32 references indexed in Scilit:
- Fabrication of high-aspect-ratio nano structures using a nano x-ray shadow maskJournal of Micromechanics and Microengineering, 2007
- Coated microneedles for transdermal deliveryJournal of Controlled Release, 2006
- A novel fabrication method of a microneedle array using inclined deep x-ray exposureJournal of Micromechanics and Microengineering, 2005
- Plain-pattern to cross-section transfer (PCT) technique for deep x-ray lithography and applicationsJournal of Micromechanics and Microengineering, 2004
- Transdermal delivery of desmopressin using a coated microneedle array patch systemJournal of Controlled Release, 2004
- Skin electroporation for transdermal and topical deliveryAdvanced Drug Delivery Reviews, 2004
- Current status and future potential of transdermal drug deliveryNature Reviews Drug Discovery, 2004
- Drug delivery across the skinExpert Opinion on Biological Therapy, 2002
- SU-8 as resist material for deep X-ray lithographyMicrosystem Technologies, 2001
- Presentation of exogenous protein antigens by dendritic cells to T cell clones. Intact protein is presented best by immature, epidermal Langerhans cells.The Journal of Experimental Medicine, 1989