Genenames.org: the HGNC and VGNC resources in 2019
Open Access
- 10 October 2018
- journal article
- research article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 47 (D1), D786-D792
- https://doi.org/10.1093/nar/gky930
Abstract
The HUGO Gene Nomenclature Committee (HGNC) based at EMBL’s European Bioinformatics Institute (EMBL-EBI) assigns unique symbols and names to human genes. There are over 40 000 approved gene symbols in our current database of which over 19 000 are for protein-coding genes. The Vertebrate Gene Nomenclature Committee (VGNC) was established in 2016 to assign standardized nomenclature in line with human for vertebrate species that lack their own nomenclature committees. The VGNC initially assigned nomenclature for over 15000 protein-coding genes in chimpanzee. We have extended this process to other vertebrate species, naming over 14000 protein-coding genes in cow and dog and over 13 000 in horse to date. Our HGNC website https://www.genenames.org has undergone a major design update, simplifying the homepage to provide easy access to our search tools and making the site more mobile friendly. Our gene families pages are now known as ‘gene groups’ and have increased in number to over 1200, with nearly half of all named genes currently assigned to at least one gene group. This article provides an overview of our online data and resources, focusing on our work over the last two years.Keywords
Funding Information
- National Human Genome Research Institute (U24HG003345)
- Wellcome Trust (208349/Z/17/Z)
This publication has 30 references indexed in Scilit:
- Forty-Four Novel Protein-Coding Loci Discovered Using a Proteomics Informed by Transcriptomics (PIT) Approach in Rat Male Germ Cells1Biology of Reproduction, 2014
- Gene: a gene-centered information resource at NCBINucleic Acids Research, 2014
- The Rat Genome Database 2015: genomic, phenotypic and environmental variations and diseaseNucleic Acids Research, 2014
- Locus Reference Genomic: reference sequences for the reporting of clinically relevant sequence variantsNucleic Acids Research, 2013
- ClinVar: public archive of relationships among sequence variation and human phenotypeNucleic Acids Research, 2013
- DECIPHER: database for the interpretation of phenotype-linked plausibly pathogenic sequence and copy-number variationNucleic Acids Research, 2013
- The chicken gene nomenclature committee reportBMC Genomics, 2009
- AmiGO: online access to ontology and annotation dataBioinformatics, 2008
- HCOP: a searchable database of human orthology predictionsBriefings in Bioinformatics, 2006
- Kazusa mammalian cDNA resources: towards functional characterization of KIAA gene productsBriefings in Functional Genomics and Proteomics, 2006