Immunochemotherapy for cutaneous leishmaniasis: a controlled trial using killed Leishmania (Leishmania) amazonensis vaccine plus antimonial
- 1 February 2002
- journal article
- clinical trial
- Published by Wiley in International Journal of Dermatology
- Vol. 41 (2), 73-78
- https://doi.org/10.1046/j.1365-4362.2002.01336.x
Abstract
Background Leishmaniasis is endemic in 88 countries in the world, and 350 million individuals are at risk of acquiring the disease. Treatment for American cutaneous leishmaniasis (ACL) is long, expensive, and associated with important side‐effects. Methods In this double‐blind, placebo‐controlled study, we treated 102 patients with ACL using either a combination of a single‐strain Leishmania amazonensis killed promastigote vaccine plus a half dose of meglumine antimoniate, or placebo plus the same half dose regimen of meglumine antimoniate, in 10‐day series followed by 10‐day intervals. Results Of the 47 patients in the experimental arm, 47 (100%) were cured after four series of treatment, compared to four of 49 (8.2%) in the control group (P < 0.0001). Six patients were lost to follow‐up. Conclusions The combination of a single‐strain Leishmania (Leishmania) amazonensis killed promastigote vaccine with a half dose regimen of antimonial is highly effective for the treatment of ACL.Keywords
This publication has 26 references indexed in Scilit:
- Treatment of Experimental Leishmaniasis with the Immunomodulators Imiquimod and S‐28463: Efficacy and Mode of ActionThe Journal of Infectious Diseases, 1999
- Phase 1 Study of an Inactivated Vaccine against American Tegumentary Leishmaniasis in Normal Volunteers in BrazilMemórias do Instituto Oswaldo Cruz, 1998
- Leishmaniasis: Public health aspects and controlClinics in Dermatology, 1996
- Vaccine for prophylaxis and immunotherapy, BrazilClinics in Dermatology, 1996
- Montenegro skin test - evaluation of the composition and stability of the antigen preparationMemórias do Instituto Oswaldo Cruz, 1996
- Practical progress and new drugs for changing patterns of leishmaniasisParasitology Today, 1993
- Estimation of population at risk of infection and number of cases of LeishmaniasisParasitology Today, 1992
- Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets.The Journal of Experimental Medicine, 1989
- Host-protective immunity and its suppression in a parasitic disease: murine cutaneous leishmaniasisImmunology Today, 1984
- THE CURATIVE VALUE OF LEISHMANIA CULTURE "VACCINE" IN ORIENTAL SOREBMJ, 1912