Molecular Cytogenetic Analysis of a Gliosarcoma with Osseous Metaplasia
- 1 May 2011
- journal article
- case report
- Published by S. Karger AG in Cytogenetic and Genome Research
- Vol. 134 (2), 88-95
- https://doi.org/10.1159/000326804
Abstract
Gliosarcoma, a rare glioblastoma variant, is composed of a glial and a mesenchymal component. Though the mesenchymal portion most commonly resembles a fibrosarcoma, other differentiation patterns have been observed. We present the first genomic characterisation (karyotyping followed by FISH and array comparative genomic hybridisation analysis) of a gliosarcoma with osseous metaplasia. In addition to chromosomal changes often found in gliomas (+7, -10, -13, and -22), the tumour cells also harboured a hitherto unknown t(3;21)(q13∼21;q21∼22).This publication has 30 references indexed in Scilit:
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