High Rate of Aminoglycoside Resistance among Staphylococci Causing Prosthetic Joint Infection
- 1 October 2005
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Clinical Orthopaedics and Related Research
- Vol. 439 (&NA;), 43-47
- https://doi.org/10.1097/01.blo.0000182394.39601.9d
Abstract
Gentamicin and tobramycin are two aminoglycosides commonly impregnated into polymethylmethacrylate for treatment and prevention of prosthetic joint infection. Susceptibilities of staphylococci to aminoglycosides are not reported routinely in the United States. The gentamicin and tobramycin minimum inhibitory value of 93 staphylococci from patients with PJI were determined. Forty-one and 66% of the isolates were resistant to gentamicin and tobramycin, respectively. Methicillin-resistant Staphylococcus aureus isolates were more likely to be resistant to gentamicin or tobramycin than were their methicillin susceptible counterparts. The findings suggest that consideration should be given to the further study of agents other than aminoglycosides for incorporation into polymethylmethacrylate for the treatment and prevention of prosthetic joint infection.Keywords
This publication has 19 references indexed in Scilit:
- Survey of Infections Due toStaphylococcusSpecies: Frequency of Occurrence and Antimicrobial Susceptibility of Isolates Collected in the United States, Canada, Latin America, Europe, and the Western Pacific Region for the SENTRY Antimicrobial Surveillance Program, 1997–1999Clinical Infectious Diseases, 2001
- Limited Role of Direct Exchange Arthroplasty in the Treatment of Infected Total Hip ReplacementsPublished by Ovid Technologies (Wolters Kluwer Health) ,2000
- Antibiotic resistance—to treat...Nature Medicine, 1999
- Risk Factors for Prosthetic Joint Infection: Case‐Control StudyClinical Infectious Diseases, 1998
- Treatment of Infection with Débridement and Retention of the Components following Hip Arthroplasty*The Journal of Bone & Joint Surgery, 1998
- Methicillin resistance in staphylococci: molecular and biochemical basis and clinical implicationsClinical Microbiology Reviews, 1997
- Use of antibiotic-impregnated cement during hip and knee arthroplasty in the United StatesThe Journal of Arthroplasty, 1995
- Local Antibacterial Therapy for the Management of Orthopaedic InfectionsClinical Pharmacokinetics, 1995
- Prophylaxis With Systematic Antibiotics Versus Gentarnicin Bone Cement in Total Hip ArthroplastyClinical Orthopaedics and Related Research, 1993
- Deep infection of cemented total hip arthroplasties caused by coagulase-negative staphylococciThe Journal of Bone and Joint Surgery. British volume, 1989