Involvement of the brain type of ryanodine receptor in T‐cell proliferation
Open Access
- 26 September 1994
- journal article
- Published by Wiley in FEBS Letters
- Vol. 352 (2), 206-210
- https://doi.org/10.1016/0014-5793(94)00955-4
Abstract
Cloning and sequence analysis of cDNA showed that the brain type of ryanodine receptor (RYR) is expressed in human Jurkat T‐lymphocyte cells. Fura‐2 measurements revealed that the RYR in T‐cells functions as a ryanodine‐sensitive, caffeine‐insensitive Ca2+ release channel. Furthermore, ryanodine stimulated proliferation and altered the growth pattern of cultured human T‐cells when added together with FK506.Keywords
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