Effects of Diabetes on the Eye
Open Access
- 1 December 2013
- journal article
- review article
- Published by Association for Research in Vision and Ophthalmology (ARVO) in Investigative Ophthalmology & Visual Science
- Vol. 54 (14), ORSF81-ORSF87
- https://doi.org/10.1167/iovs.13-12979
Abstract
Hyperglycemia has toxic effects on almost all cells in the body. Ophthalmic complications of hyperglycemia are most profound in cornea and retina. Seventy percent of diabetics suffer from corneal complications, collectively called diabetic keratopathy, which includes include recurrent erosions, delayed wound healing, ulcers, and edema. Confocal microscopy has permitted in vivo imaging of corneal nerves, which are also affected in diabetic subjects. Gene therapies upregulating MNNG HOS transforming gene (cMet) and/or downregulating MMP10 and cathepsin S are potential future therapies for diabetic keratopathy.Keywords
This publication has 46 references indexed in Scilit:
- Imaging and Quantification of Subbasal Nerve Plexus in Healthy Volunteers and Diabetic Patients with or without RetinopathyPLOS ONE, 2013
- Growth Factor-Activated Stem Cell Circuits and Stromal Signals Cooperatively Accelerate Non-Integrated iPSC Reprogramming of Human Myeloid ProgenitorsPLOS ONE, 2012
- Mapping the Nerve Architecture of Diabetic Human CorneasOphthalmology, 2012
- Leukocyte Adhesion Molecules in Diabetic RetinopathyJournal of Ophthalmology, 2011
- Corneal Complications in Streptozocin-Induced Type I Diabetic RatsInvestigative Ophthalmology & Visual Science, 2011
- Blockade of NADPH Oxidase Restores Vasoreparative Function in Diabetic CD34+CellsInvestigative Ophthalmology & Visual Science, 2011
- Cell-Based Therapies for Diabetic RetinopathyCurrent Diabetes Reports, 2011
- Normalization of Wound Healing and Diabetic Markers in Organ Cultured Human Diabetic Corneas by Adenoviral Delivery ofc-MetGeneInvestigative Ophthalmology & Visual Science, 2010
- Adenovirus-driven overexpression of proteinases in organ-cultured normal human corneas leads to diabetic-like changesBrain Research Bulletin, 2009
- Contributions of Inflammatory Processes to the Development of the Early Stages of Diabetic RetinopathyExperimental Diabetes Research, 2007