Gestational malaria associated to Plasmodium vivax and Plasmodium falciparum placental mixed-infection followed by foetal loss: a case report from an unstable transmission area in Brazil
Open Access
- 27 June 2011
- journal article
- research article
- Published by Springer Science and Business Media LLC in Malaria Journal
- Vol. 10 (1), 178
- https://doi.org/10.1186/1475-2875-10-178
Abstract
Gestational malaria is a multi-factorial syndrome leading to poor outcomes for both the mother and foetus. Although an unusual increasing in the number of hospitalizations caused by Plasmodium vivax has been reported in Brazil, mortality is rarely observed. This is a report of a gestational malaria case that occurred in the city of Manaus (Amazonas State, Brazil) and resulted in foetal loss. The patient presented placental mixed-infection by Plasmodium vivax and Plasmodium falciparum after diagnosis by nested-PCR, however microscopic analysis failed to detect P. falciparum in the peripheral blood. Furthermore, as the patient did not receive proper treatment for P. falciparum and hospitalization occurred soon after drug treatment, it seems that P. falciparum pathology was modulated by the concurrent presence of P. vivax. Collectively, this case confirms the tropism towards the placenta by both of these species of parasites, reinforces the notion that co-existence of distinct malaria parasites interferes on diseases' outcomes, and opens discussions regarding diagnostic methods, malaria treatment during pregnancy and prenatal care for women living in unstable transmission areas of malaria, such as the Brazilian Amazon.This publication has 20 references indexed in Scilit:
- Malaria in Brazil: an overviewMalaria Journal, 2010
- Immune response toPlasmodium vivaxhas a potential to reduce malaria severityClinical and Experimental Immunology, 2009
- Malaria Diagnosis and Hospitalization Trends, BrazilEmerging Infectious Diseases, 2007
- Chloroquine-ResistantPlasmodiumvivax, Brazilian AmazonEmerging Infectious Diseases, 2007
- Cytoadhesion of Plasmodium falciparum-infected erythrocytes and the infected placenta: a two-way pathwayBrazilian Journal of Medical and Biological Research, 2006
- A family affair: var genes, PfEMP1 binding, and malaria diseaseCurrent Opinion in Microbiology, 2006
- The co-existence of Plasmodium: sidelights from falciparum and vivax malaria in ThailandTrends in Parasitology, 2004
- Virulence in malaria: an evolutionary viewpointPhilosophical Transactions Of The Royal Society B-Biological Sciences, 2004
- Maternal malaria: Plasmodium falciparum sequestration in the placentaZeitschrift für Parasitenkunde, 2002
- Molecular mechanisms of Plasmodium falciparum placental adhesion . MicroreviewCellular Microbiology, 2001