Radiation Recall with Anticancer Agents
Open Access
- 1 November 2010
- journal article
- case report
- Published by Oxford University Press (OUP) in The Oncologist
- Vol. 15 (11), 1227-1237
- https://doi.org/10.1634/theoncologist.2009-0090
Abstract
Radiation recall is an acute inflammatory reaction confined to previously irradiated areas that can be triggered when chemotherapy agents are administered after radiotherapy. It remains a poorly understood phenomenon, but increased awareness may aid early diagnosis and appropriate management. A diverse range of drugs used in the treatment of cancer has been associated with radiation recall. As most data come from case reports, it is not possible to determine the true incidence, but to date the antineoplastic drugs for which radiation recall reactions have been most commonly reported include the anthracycline doxorubicin, the taxanes docetaxel and paclitaxel, and the antimetabolites gemcitabine and capecitabine. Radiation recall is drug-specific for any individual patient; it is not possible to predict which patients will react to which drugs, and rechallenge does not uniformly induce a reaction. There are no identifiable characteristics of drugs that cause radiation recall, and thus, it is a possibility that must be kept in mind with use of any drug after radiotherapy, including those from new drug classes. Although it is not yet possible to design treatment regimens to eliminate the risk of radiation recall, it seems likely that risks can be minimized by prolonging the interval between completion of radiotherapy and initiation of chemotherapy.Keywords
This publication has 108 references indexed in Scilit:
- Radiation Recall Dermatitis with Cefotetan: A Case StudyThe Oncologist, 2006
- Radiation Recall Dermatitis after the Use of the Anorexiant Phentermine in a Patient with Breast CancerThe Breast Journal, 2006
- Radiation recall: A well recognized but neglected phenomenonCancer Treatment Reviews, 2005
- Radiation recall dermatitis after docetaxel administration: absolute indication to replace the drug?British Journal of Dermatology, 2005
- A case of radiation recall mucositis associated with docetaxelHead & Neck, 2004
- Radiation recall dermatitis induced by pegylated liposomal doxorubicinAnti-Cancer Drugs, 2003
- Histopathologic Features Seen with Radiation Recall or Enhancement EruptionsJournal of Cutaneous Medicine and Surgery, 2002
- Radiation Recall with Oxaliplatin: Report of a Case and a Review of the LitertureClinical Oncology, 2001
- Cutaneous complications of chemotherapeutic agentsJournal of the American Academy of Dermatology, 1983
- SKIN REACTION TO VINBLASTINEThe Lancet, 1969