Mapping biochemistry to metabolism
- 1 September 1999
- journal article
- case report
- Published by Ovid Technologies (Wolters Kluwer Health) in NeuroReport
- Vol. 10 (14), 2911-2917
- https://doi.org/10.1097/00001756-199909290-00007
Abstract
We evaluated the relationship between amyloid-beta protein (A beta) concentration and the metabolic abnormality in an Alzheimer's disease (AD) patient as measured by [18F]fluorodeoxyglucose positron emission tomography (FDG-PET). Across most regions there were significant inverse correlations among FDG-PET intensity values and both insoluble. The temporal lobe samples showed no significant correlation between FDG-PET values and A beta deposition. Findings support A beta as contributing to the hypometabolism in regions of the AD brain that are still relatively viable metabolically; those regions with chronic pathologic damage, such as temporal cortex, may have other factors that contribute to metabolic deficits.Keywords
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