Satisfaction (not) guaranteed: re-evaluating the use of animal models of type 1 diabetes
- 1 December 2004
- journal article
- Published by Springer Science and Business Media LLC in Nature Reviews Immunology
- Vol. 4 (12), 989-997
- https://doi.org/10.1038/nri1502
Abstract
Without a doubt, rodent models have been instrumental in describing pathways that lead to pancreatic beta-cell destruction, evaluating potential causes of type 1 diabetes and providing proof-of-principle for the potential of immune-based interventions. However, despite more than two decades of productive research, we are still yet to define an initiating autoantigen for the human disease, to determine the precise mechanisms of beta-cell destruction in humans and to design interventions that prevent or cure type 1 diabetes. In this Perspective article, we propose that a major philosophical change would benefit this field, a proposition that is based on evaluation of situations in which rodent models have provided useful guidance and in which they have led to disappointments.Keywords
This publication has 120 references indexed in Scilit:
- Recessive tolerance to preproinsulin 2 reduces but does not abolish type 1 diabetesNature Immunology, 2004
- The TCR-HA, INS-HA transgenic model of autoimmune diabetes: limitations and expectationsJournal of Autoimmunity, 2004
- T-cell receptor-transgenic NOD mice: a reductionist approach to understand autoimmune diabetesJournal of Autoimmunity, 2004
- TNF-α impairs peripheral tolerance towards β-cells, and local costimulation by B7.1 enhances the effector function of diabetogenic T cellsEuropean Journal of Immunology, 2003
- T Cell Response in Experimental Autoimmune Encephalomyelitis (EAE): Role of Self and Cross-Reactive Antigens in Shaping, Tuning, and Regulating the Autopathogenic T Cell RepertoireAnnual Review of Immunology, 2002
- Development of Type 1 Diabetes despite Severe Hereditary B-Cell DeficiencyNew England Journal of Medicine, 2001
- Control of Autoimmune Diabetes in NOD Mice by GAD Expression or Suppression in β CellsScience, 1999
- Dendritic Cells Induce Autoimmune Diabetes and Maintain Disease via De Novo Formation of Local Lymphoid TissueThe Journal of Experimental Medicine, 1998
- NOD mouse colonies around the world- recent facts and figuresImmunology Today, 1993
- Split tolerance of Thl and Th2 cells in tolerance to Theiler's murine encephalomyelitis virusEuropean Journal of Immunology, 1993