Stability and prognostic influence of FLT3 mutations in paired initial and relapsed AML samples
Open Access
- 27 April 2006
- journal article
- research article
- Published by Springer Science and Business Media LLC in Leukemia
- Vol. 20 (7), 1217-1220
- https://doi.org/10.1038/sj.leu.2404246
Abstract
In acute myeloid leukemia (AML), activating mutations in the fms-like tyrosine kinase 3 (FLT3) gene predict poor prognosis. We determined FLT3 internal tandem duplications (FLT3/ITD) and D835 point mutations in paired initial and relapse samples from 80 pediatric and adult AML patients. One D835 point mutation was found in an initial pediatric AML sample. Fms-like tyrosine kinase 3/ITDs were present in 21 initial and 22 relapse samples (26.3 and 27.5%, respectively). Interestingly, FLT3/ITD positivity was related to a significantly shorter time to relapse, most pronounced when the ITD-positive status was found at relapse (PFms-like tyrosine kinase 3/ITD is a relevant marker for prognosis, and remains an important target for therapeutic inhibition.Keywords
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