Kinetic Resolution of Indolines by Pd-Catalyzed Asymmetric Allylic Amination
- 20 March 2009
- journal article
- letter
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 11 (8), 1789-1791
- https://doi.org/10.1021/ol9002543
Abstract
The kinetic resolution of indolines was realized via a Pd-catalyzed allylic substitution reaction by using Trost's chiral ligand L10, affording optically active indolines and N-allylated indolines in high yields and high enantioselectivities with an S factor up to 59, which provided the first example for the kinetic resolution of nucleophiles via a transition-metal-catalyzed allylic substitution reaction.Keywords
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