DONOR ORIGIN OF A POSTTRANSPLANT LIVER ALLOGRAFT MALIGNANCY IDENTIFIED BY FLUORESCENCE IN SITU HYBRIDIZATION FOR THE Y CHROMOSOME AND DNA GENOTYPING
- 1 January 1997
- journal article
- case report
- Published by Ovid Technologies (Wolters Kluwer Health) in Transplantation
- Vol. 63 (1), 80-84
- https://doi.org/10.1097/00007890-199701150-00015
Abstract
Posttransplantation malignancy in the allograft is a rare complication of orthotopic liver transplantation. In the described case, an abnormal T-tube cholangiogram, performed 6 months after orthotopic liver transplantation between a male donor and a female recipient, prompted needle liver biopsy. A moderately differentiated adenocarcinoma was found. Fluorescence in situ hybridization for the Y chromosome indicated male origin of malignancy. Donor-related disease was confirmed by comparative DNA analysis of genomic sequences from the donor liver, associated tumor, and recipient peripheral blood. Results of these investigations qualified the recipient for a second liver transplant.Keywords
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