Influence of the pKa value of the buried, active‐site cysteine on the redox properties of thioredoxin‐like oxidoreductases

Abstract
Thioredoxin constitutes the prototype of the thiol‐disulfide oxidoreductase family. These enzymes contain an active‐site disulfide bridge with the consensus sequence Cys‐Xaa‐Xaa‐Cys. The more N‐termi...