Cyr61 is a potential prognostic marker for prostate cancer
Open Access
- 20 February 2012
- journal article
- review article
- Published by Medknow in Asian Journal of Andrology
- Vol. 14 (3), 405-408
- https://doi.org/10.1038/aja.2011.149
Abstract
Cysteine-rich angiogenic inducer 61 (Cyr61) is an extracellular matrix protein involved in the transduction of growth factor and hormone signaling that is frequently altered in expression in several types of cancers. In prostate cancer (PCa), Cyr61 is highly expressed in organ-confined disease. Further, Cyr61 expression levels are associated with a lower risk of disease recurrence, and can be quantitatively measured in the serum. Considered together, these results indicate that Cyr61 is a potential and clinically useful tissue, as well as serum-based biomarker for differentiating lethal and non-lethal PCa.Keywords
This publication has 45 references indexed in Scilit:
- Cyr61 is regulated by cAMP‐dependent protein kinase with serum levels correlating with prostate cancer aggressivenessThe Prostate, 2011
- Decreased Expression of Cyr61 Is Associated with Prostate Cancer Recurrence after Surgical TreatmentClinical Cancer Research, 2010
- Extracellular Matrix Associated Protein CYR61 is Linked to Prostate Cancer DevelopmentJournal of Urology, 2010
- Matrix Protein CCN1 Is Critical for Prostate Carcinoma Cell Proliferation and TRAIL-Induced ApoptosisMolecular Cancer Research, 2009
- Functions and mechanisms of action of CCN matricellular proteinsThe International Journal of Biochemistry & Cell Biology, 2009
- Involvement of Cyr61 in growth, migration, and metastasis of prostate cancer cellsBritish Journal of Cancer, 2008
- Diagnosis of adenocarcinoma in prostate needle biopsy tissueJournal of Clinical Pathology, 2007
- Increased expression of Cyr61 (CCN1) identified in peritoneal metastases from human pancreatic cancerJournal of the American College of Surgeons, 2005
- Cyr61 Is Overexpressed in Gliomas and Involved in Integrin-Linked Kinase-Mediated Akt and β-Catenin-TCF/Lef Signaling PathwaysCancer Research, 2004
- The angiogenic factor CYR61 in breast cancer: molecular pathology and therapeutic perspectives.Endocrine-Related Cancer, 2003