Economic burden of recurrent venous thromboembolism: Analysis from a U.S. hospital perspective
- 15 February 2015
- journal article
- Published by Oxford University Press (OUP) in American Journal of Health-System Pharmacy
- Vol. 72 (4), 291-300
- https://doi.org/10.2146/ajhp140204
Abstract
Purpose An analysis of resource utilization and hospital costs associated with recurrent venous thromboembolism (VTE) is presented. Methods A retrospective cohort analysis was conducted using a large U.S. hospital database. Patients with VTE-related hospitalization events during the period January–December 2010 were identified; data collection extended for up to 12 months after the index event. Postdischarge hospital resource use and total costs were compared in cohorts of patients with and without recurrent VTE. Regression analysis was performed to compare hospital costs and length of stay (LOS) during initial and subsequent VTE encounters. Results Among the study population of 43,734 patients, 4% had postdischarge VTE-related events during the data collection period. The median and mean ± S.D. times to VTE recurrence were 48 days and 98 ± 106 days, respectively. Patients with recurrent VTE had more all-cause hospitalizations than those without recurrent VTE (mean ± S.D., 1.07 ± 0.96 versus 0.15 ± 0.53; p < 0.0001), more all-cause emergency room visits (mean ± S.D., 0.31 ± 0.66 versus 0.05 ± 0.31; p < 0.0001), and greater total costs (mean ± S.D., $28,353 ± $39,624 versus $17,712 ± $33,461; p < 0.0001). Relative to initial VTE admissions, admissions for recurrent VTE were, on average, associated with a 14% longer LOS (p = 0.0002) and a 22% higher total cost (p < 0.001). Conclusion Patients with recurrent VTE used more hospital resources than those without recurrent VTE. Readmissions for VTE were significantly longer and more costly than index encounters.Keywords
This publication has 30 references indexed in Scilit:
- Heparin and warfarin anticoagulation intensity as predictors of recurrence after deep vein thrombosis or pulmonary embolism: a population-based cohort studyBlood, 2011
- Impact and clinical significance of recurrent venous thromboembolismBritish Journal of Surgery, 2010
- Recurrent venous thromboembolism after surgery-provoked versus unprovoked thromboembolismJournal of Thrombosis and Haemostasis, 2010
- Venous Thromboembolism: A Public Health ConcernAmerican Journal of Preventive Medicine, 2010
- Are There Any Differences in the Clinical and Economic Outcomes Between US Cancer Patients Receiving Appropriate or Inappropriate Venous Thromboembolism Prophylaxis?Journal of Oncology Practice, 2009
- Venous ThromboembolismArteriosclerosis, Thrombosis, and Vascular Biology, 2009
- Comparison of cost, effectiveness, and safety of injectable anticoagulants used for thromboprophylaxis after orthopedic surgeryAmerican Journal of Health-System Pharmacy, 2007
- Incidence and mortality of venous thrombosis: a population‐based studyJournal of Thrombosis and Haemostasis, 2007
- Economic burden of deep-vein thrombosis, pulmonary embolism, and post-thrombotic syndromeAmerican Journal of Health-System Pharmacy, 2006
- Deep vein thrombosis and pulmonary embolism in two cohorts: the longitudinal investigation of thromboembolism etiologyAmerican Journal Of Medicine, 2004