Meta-analysis identifies common variants associated with body mass index in east Asians
Open Access
- 19 February 2012
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature Genetics
- Vol. 44 (3), 307-311
- https://doi.org/10.1038/ng.1087
Abstract
Xiao-Ou Shu and colleagues report a meta-analysis of genome-wide association studies for body mass index (BMI) in east Asians. They identify three new genetic loci associated with BMI. Multiple genetic loci associated with obesity or body mass index (BMI) have been identified through genome-wide association studies conducted predominantly in populations of European ancestry. We performed a meta-analysis of associations between BMI and approximately 2.4 million SNPs in 27,715 east Asians, which was followed by in silico and de novo replication studies in 37,691 and 17,642 additional east Asians, respectively. We identified ten BMI-associated loci at genome-wide significance (P < 5.0 × 10−8), including seven previously identified loci (FTO, SEC16B, MC4R, GIPR-QPCTL, ADCY3-DNAJC27, BDNF and MAP2K5) and three novel loci in or near the CDKAL1, PCSK1 and GP2 genes. Three additional loci nearly reached the genome-wide significance threshold, including two previously identified loci in the GNPDA2 and TFAP2B genes and a newly identified signal near PAX6, all of which were associated with BMI with P < 5.0 × 10−7. Findings from this study may shed light on new pathways involved in obesity and demonstrate the value of conducting genetic studies in non-European populations.This publication has 79 references indexed in Scilit:
- Genomics, Type 2 Diabetes, and ObesityThe New England Journal of Medicine, 2010
- Association analyses of 249,796 individuals reveal 18 new loci associated with body mass indexNature Genetics, 2010
- Twelve type 2 diabetes susceptibility loci identified through large-scale association analysisNature Genetics, 2010
- Discovery of common Asian copy number variants using integrated high-resolution array CGH and massively parallel DNA sequencingNature Genetics, 2010
- Transcriptome genetics using second generation sequencing in a Caucasian populationNature, 2010
- Six new loci associated with body mass index highlight a neuronal influence on body weight regulationNature Genetics, 2008
- Common variants near MC4R are associated with fat mass, weight and risk of obesityNature Genetics, 2008
- A second generation human haplotype map of over 3.1 million SNPsNature, 2007
- Structural variation in the human genomeNature Reviews Genetics, 2006
- STAT3 signalling is required for leptin regulation of energy balance but not reproductionNature, 2003