Activating mutations in CSF1R and additional receptor tyrosine kinases in histiocytic neoplasms
Top Cited Papers
- 25 November 2019
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature Medicine
- Vol. 25 (12), 1839-1842
- https://doi.org/10.1038/s41591-019-0653-6
Abstract
Histiocytoses are clonal hematopoietic disorders frequently driven by mutations mapping to the BRAF and MEK1 and MEK2 kinases. Currently, however, the developmental origins of histiocytoses in patients are not well understood, and clinically meaningful therapeutic targets outside of BRAF and MEK are undefined. In this study, we uncovered activating mutations in CSF1R and rearrangements in RET and ALK that conferred dramatic responses to selective inhibition of RET (selpercatinib) and crizotinib, respectively, in patients with histiocytosis.Funding Information
- U.S. Department of Health & Human Services | NIH | National Cancer Institute (1 R01 CA201247, K08 CA218901)
- U.S. Department of Health & Human Services | NIH | National Cancer Institute
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