Total Synthesis of Ecteinascidin 743
- 7 December 2005
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 128 (1), 87-89
- https://doi.org/10.1021/ja0571794
Abstract
A convergent total synthesis of ecteinascidin 743 is realized from five building blocks of almost equal size. It takes 23 steps from l-3-hydroxy-4-methoxy-5-methyl phenylalanol (5) with an overall yield of 3%.Keywords
This publication has 19 references indexed in Scilit:
- A Practical Synthesis of the ABC Ring Model of Ecteinascidins.CHEMICAL & PHARMACEUTICAL BULLETIN, 2000
- 4-Nitrophenyltriflate and 4-Nitrophenylnonaflate as New Perfluoroalkanesulfonyl Transfer Agents: Experimental and Computational StudiesThe Journal of Organic Chemistry, 1999
- Palladium-Catalyzed Cross-Coupling Reactions of Organoboron CompoundsChemical Reviews, 1995
- Ecteinascidins 729, 743, 745, 759A, 759B, and 770: potent antitumor agents from the Caribbean tunicate Ecteinascidia turbinata [Erratum to document cited in CA113(9):75189d]The Journal of Organic Chemistry, 1991
- Antitumor tetrahydroisoquinoline alkaloids from the colonial ascidian Ecteinascidia turbinataThe Journal of Organic Chemistry, 1990
- Potassium fluoride catalyzed fluorodesulfonylations of aryl sulfonyl fluoridesThe Journal of Organic Chemistry, 1988
- Enantioselective ring construction with control of side-chain stereochemistry. Synthesis of (+)-isoneonepetalactoneThe Journal of Organic Chemistry, 1988
- Novel preparation of N-protected amino acid active esters using 1,2,2,2-tetrachloroethyl carbonatesThe Journal of Organic Chemistry, 1987
- Involvement of the azide radical in the quenching of singlet oxygen by azide anion in waterJournal of the American Chemical Society, 1982
- PyracyloquinoneJournal of the American Chemical Society, 1966