Highly flexible, wearable, and disposable cardiac biosensors for remote and ambulatory monitoring
Open Access
- 25 January 2018
- journal article
- research article
- Published by Springer Science and Business Media LLC in npj Digital Medicine
- Vol. 1 (1), 1-8
- https://doi.org/10.1038/s41746-017-0009-x
Abstract
Contemporary cardiac and heart rate monitoring devices capture physiological signals using optical and electrode-based sensors. However, these devices generally lack the form factor and mechanical flexibility necessary for use in ambulatory and home environments. Here, we report an ultrathin (~1 mm average thickness) and highly flexible wearable cardiac sensor (WiSP) designed to be minimal in cost (disposable), light weight (1.2 g), water resistant, and capable of wireless energy harvesting. Theoretical analyses of system-level bending mechanics show the advantages of WiSP’s flexible electronics, soft encapsulation layers and bioadhesives, enabling intimate skin coupling. A clinical feasibility study conducted in atrial fibrillation patients demonstrates that the WiSP device effectively measures cardiac signals matching the Holter monitor, and is more comfortable. WiSP’s physical attributes and performance results demonstrate its utility for monitoring cardiac signals during daily activity, exertion and sleep, with implications for home-based care.Keywords
This publication has 46 references indexed in Scilit:
- Ultrathin conformal devices for precise and continuous thermal characterization of human skinNature Materials, 2013
- Flexible and Stretchable Electronics for Biointegrated DevicesAnnual Review of Biomedical Engineering, 2012
- Mechanics of Epidermal ElectronicsJournal of Applied Mechanics, 2012
- A user-friendly integrated monitor-adhesive patch for long-term ambulatory electrocardiogram monitoringJournal of Electrocardiology, 2012
- Skin-like pressure and strain sensors based on transparent elastic films of carbon nanotubesNature Nanotechnology, 2011
- Best Electrode Locations for a Small Bipolar ECG Device: Signal Strength Analysis of Clinical DataAnnals of Biomedical Engineering, 2008
- Agreement Between Methods of Measurement with Multiple Observations Per IndividualJournal of Biopharmaceutical Statistics, 2007
- Can we improve cardiovascular risk prediction beyond risk equations in the physician's office?Journal of Clinical Epidemiology, 2006
- Bedside risk stratification after acute myocardial infarction: Prospective evaluation of the use of heart rate and left ventricular functionJournal of Electrocardiology, 2005
- Operational definition of normal sinus heart rateThe American Journal of Cardiology, 1992