Salmonella mutagenicity tests: V. Results from the testing of 311 chemicals
- 1 January 1992
- journal article
- research article
- Published by Wiley in Environmental and Molecular Mutagenesis
- Vol. 19 (S21), 2-141
- https://doi.org/10.1002/em.2850190603
Abstract
311 chemicals were tested under code, for mutagenicity, in Salmonella typhimurium; 35 of the chemicals were tested more than once in the same or different laboratories. The tests were conducted using a preincubation protocol in the absence of exogenous metabolic activation, and in the presence of liver S-9 from Aroclor-induced male Sprague-Dawley rats and Syrian hamsters. Some of the volatile chemicals were also tested in desiccators. A total of 120 chemicals were mutagenic or weakly mutagenic, 3 were judged questionable, and 172 were non-mutagenic. The remaining 16 chemicals produced different responses in the two or three laboratories in which they were tested. The results and data from these tests are presented.Keywords
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