Similarity of Synthetic Peptide from Human Tumor to Parathyroid Hormone in Vivo and in Vitro
- 11 December 1987
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 238 (4833), 1566-1568
- https://doi.org/10.1126/science.3685994
Abstract
One mechanism considered responsible for the hypercalcemia that frequently accompanies malignancy is secretion by the tumor of a circulating factor that alters calcium metabolism. The structure of a tumor-secreted peptide was recently determined and found to be partially homologous to parathyroid hormone (PTH). The amino-terminal 1-34 region of the factor was synthesized and evaluated biologically. In vivo it produced hypercalcemia, acted on bone and kidney, and stimulated 1,25-dihydroxy-vitamin D3 formation. In vitro it interacted with PTH receptors and, in some systems, was more potent than PTH. These studies support a long-standing hypothesis regarding pathogenesis of malignancy-associated hypercalcemia.This publication has 26 references indexed in Scilit:
- N-Terminal amino acid sequence of two novel tumor-derived adenylate cyclase-stimulating proteins: Identification of parathyroid hormone-like and parathyroid hormone-unlike domainsBiochemical and Biophysical Research Communications, 1987
- Peptide Hormone Antagonists That Are Effective in VivoNew England Journal of Medicine, 1986
- Humoral hypercalcemia of malignancy. Release of a prostaglandin-stimulating bone-resorbing factor in vitro by human transitional-cell carcinoma cells.JCI Insight, 1986
- Factors associated with humoral hypercalcemia of malignancy stimulate adenylate cyclase in osteoblastic cells.JCI Insight, 1983
- Absence of Parathyroid Hormone Messenger RNA in Nonparathyroid Tumors Associated with HypercalcemiaNew England Journal of Medicine, 1983
- A Parathyroid Hormone Inhibitor in Vivo: Design and Biological Evaluation of a Hormone AnalogScience, 1983
- Biochemical Evaluation of Patients with Cancer-Associated HypercalcemiaNew England Journal of Medicine, 1980
- Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reactionBiochemical Pharmacology, 1973
- Solid‐Phase Peptide SynthesisAdvances In Enzymology and Related Subjects Of Biochemistry, 1969
- A Multiple Comparison Procedure for Comparing Several Treatments with a ControlJournal of the American Statistical Association, 1955