The emergence and analysis of synthetic cannabinoids
- 21 February 2011
- journal article
- research article
- Published by Wiley in Drug Testing and Analysis
- Vol. 3 (7-8), 466-478
- https://doi.org/10.1002/dta.268
Abstract
In late 2008, several synthetic cannabinoids were detected in herbal smoking mixtures. Typical of these products were ‘Spice Gold’, ‘Spice Silver’ and ‘Yucatan Fire’, but many other products have since appeared. The analytes detected, such as JWH-018 and CP47,497 are experimental compounds, some of which were never designed for human use. Both scientific and anecdotal evidence suggest that these compounds are more potent than traditional cannabis and are being widely used. As a result, authorities around the world are now beginning to control them by either naming individual compounds or using generic legislation. This, however, is easier said than done as the synthetic cannabinoids detected are constantly changing in attempts by manufacturers to evade legislation. This paper includes background information in the style of a brief monograph, as an aid to rapidly understanding the pharmacological aspects of these compounds in the forensic context, and then presents a comprehensive set of data, obtained from analysis of purchased products by gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-tandem mass spectrometry (LC-MS/MS). Copyright © 2011 John Wiley & Sons, Ltd.Keywords
This publication has 23 references indexed in Scilit:
- Use of High-Resolution Accurate Mass Spectrometry to Detect Reported and Previously Unreported Cannabinomimetics in "Herbal High" ProductsJournal of Analytical Toxicology, 2010
- Spice: A never ending story?Forensic Science International, 2009
- Identification of a cannabimimetic indole as a designer drug in a herbal productForensic Toxicology, 2009
- ‘Spice’ and other herbal blends: harmless incense or cannabinoid designer drugs?Journal of Mass Spectrometry, 2009
- Identification of a Cannabinoid Analog as a New Type of Designer Drug in a Herbal ProductCHEMICAL & PHARMACEUTICAL BULLETIN, 2009
- Novel cannabinoid receptorsBritish Journal of Pharmacology, 2007
- Adverse effects of cannabis and cannabinoidsBritish Journal of Anaesthesia, 1999
- Adverse effects of cannabisThe Lancet, 1998
- Molecular characterization of a peripheral receptor for cannabinoidsNature, 1993
- Structure of a cannabinoid receptor and functional expression of the cloned cDNANature, 1990