Adaptation of the bacterial membrane to changing environments using aminoacylated phospholipids
Open Access
- 14 January 2009
- journal article
- editorial
- Published by Wiley in Molecular Microbiology
- Vol. 71 (3), 547-550
- https://doi.org/10.1111/j.1365-2958.2008.06563.x
Abstract
Fine‐tuning of the biophysical properties of biological membranes is essential for adaptation of cells to changing environments. For instance, to lower the negative charge of the lipid bilayer, certain bacteria add lysine to phosphatidylglycerol (PG) converting the net negative charge of PG (−1) to a net positive charge in Lys‐PG (+1). Reducing the net negative charge of the bacterial cell wall is a common strategy used by bacteria to resist cationic antimicrobial peptides (CAMPs) secreted by other microbes or produced by the innate immune system of a host organism. The article by Klein et al. in the current issue of Molecular Microbiology reports a new modification of the bacterial membrane, addition of alanine to PG, in Pseudomonas aeruginosa. In spite of the neutral charge of Ala‐PG, this modified lipid was found to be linked to several resistance phenotypes in P. aeruginosa. For instance, Ala‐PG increases resistance to two positively charged antibacterial agents, a β‐lactam and high concentrations of lactate. These findings shed light on the mechanisms by which bacteria fine‐tune the properties of their cell membranes by adding various amino acids on the polar head group of phospholipids.Keywords
This publication has 12 references indexed in Scilit:
- Adaptation of Pseudomonas aeruginosa to various conditions includes tRNA‐dependent formation of alanyl‐phosphatidylglycerolMolecular Microbiology, 2008
- Lipid domains in bacterial membranesMolecular Microbiology, 2006
- The co-evolution of host cationic antimicrobial peptides and microbial resistanceNature Reviews Microbiology, 2006
- Pore Size Dependence on Growth Temperature Is a Common Characteristic of the Major Outer Membrane Protein OprF in Psychrotrophic and Mesophilic Pseudomonas SpeciesApplied and Environmental Microbiology, 2004
- Molecular Basis of Bacterial Outer Membrane Permeability RevisitedMicrobiology and Molecular Biology Reviews, 2003
- Bacterial Membrane Lipids: Where Do We Stand?Annual Review of Microbiology, 2003
- Lipid–protein interactions in biological membranes: a structural perspectiveBiochimica et Biophysica Acta (BBA) - Biomembranes, 2003
- Escherichia coli O157 and Non-O157 Isolates Are More Susceptible to l -Lactate than to d -LactateApplied and Environmental Microbiology, 2002
- Staphylococcus aureus Resistance to Human Defensins and Evasion of Neutrophil Killing via the Novel Virulence Factor Mprf Is Based on Modification of Membrane Lipids with l-LysineThe Journal of Experimental Medicine, 2001
- The bacterial outer membrane as a drug barrierTrends in Microbiology, 1997