Associated clinical factors for serious infections in patients with systemic lupus erythematosus
Open Access
- 4 July 2019
- journal article
- research article
- Published by Springer Science and Business Media LLC in Scientific Reports
- Vol. 9 (1), 1-8
- https://doi.org/10.1038/s41598-019-46039-5
Abstract
Infection occurs frequently in patients with systemic lupus erythematosus (SLE), and has been a major cause of morbidity and mortality. However, no large-scale comprehensive studies have estimated the effect of clinical characteristics on serious infection in actual clinical practice yet. We investigated the influence of clinical characteristics on serious infections using electronic medical records data. We conducted a nested case-control study. Patients with SLE who developed serious infection which needs hospitalization or intravenous antibiotics (n = 120) were matched to controls (n = 240) who didn’t. Odds ratios (OR) and 95% confidence intervals (CIs) for infection associated with clinical features were obtained by conditional logistic regression analyses. The conditional logistic regression analysis with adjustment showed that serositis (OR, 2.76; 95% CI, 1.33–5.74), hematologic involvement (OR, 2.53; 95% CI, 1.32–4.87), and use of higher than the low dose of glucocorticoids (GCs; >7.5 mg/d prednisolone-equivalent) (OR, 2.65; 95% CI, 1.31–5.34) were related to serious infections in SLE. Serositis, hematologic involvement, and use of higher than the low dose of GCs were associated with serious infections in patients with SLE.Keywords
This publication has 40 references indexed in Scilit:
- Systemic lupus erythematosus and infections: Clinical importance of conventional and upcoming biomarkersAutoimmunity Reviews, 2012
- The association between systemic glucocorticoid therapy and the risk of infection in patients with rheumatoid arthritis: systematic review and meta-analysesArthritis Research & Therapy, 2011
- Infections in systemic lupus erythematosusLupus, 2010
- Serious infections in British patients with systemic lupus erythematosus: hospitalisations and mortalityLupus, 2009
- Predictors of major infections in systemic lupus erythematosusArthritis Research & Therapy, 2009
- Incidence and risk factors of infection in a single cohort of 110 adults with systemic lupus erythematosusScandinavian Journal of Infectious Diseases, 2009
- Infections in systemic lupus erythematosus: a prospective and controlled study of 110 patientsLupus, 2006
- Risk factors and prognostic influence of infection in a single cohort of 87 adults with systemic lupus erythematosusAnnals Of The Rheumatic Diseases, 2001
- Predicting Infection in Hospitalized Patients with Systemic Lupus Erythematosus.Internal Medicine, 1996
- DeflazacortDrugs, 1995