Parkinson’s disease and sleepiness
- 9 April 2002
- journal article
- Published by Ovid Technologies (Wolters Kluwer Health) in Neurology
- Vol. 58 (7), 1019-1024
- https://doi.org/10.1212/wnl.58.7.1019
Abstract
Objective: To investigate the potential causes of excessive daytime sleepiness in patients with PD—poor sleep quality, abnormal sleep–wakefulness control, and treatment with dopaminergic agents. Methods: The authors performed night-time polysomnography and daytime multiple sleep latency tests in 54 consecutive levodopa-treated patients with PD referred for sleepiness, 27 of whom were also receiving dopaminergic agonists. Results: Sleep latency was 6.3 ± 0.6 minutes (normal >8 minutes), and the Epworth Sleepiness score was 14.3 ± 4.1 (normal 15/h; range 15.1 to 50.0). Severity of sleepiness was weakly correlated with Epworth Sleepiness score (r = −0.34) and daily dose of levodopa (r = 0.30) but not with dopamine-agonist treatment, age, disease duration, parkinsonian motor disability, total sleep time, periodic leg movement, apnea–hypopnea, or arousal indices. Conclusions: In patients with PD preselected for sleepiness, severity of sleepiness was not dependent on nocturnal sleep abnormalities, motor and cognitive impairment, or antiparkinsonian treatment. The results suggest that sleepiness—sudden onset of sleep—does not result from pharmacotherapy but is related to the pathology of PD.Keywords
This publication has 23 references indexed in Scilit:
- Effects of Levodopa on Pulmonary Function in Parkinson's DiseaseSocial psychiatry. Sozialpsychiatrie. Psychiatrie sociale, 2001
- Neuroimmunoregulation of Androgens in the Adrenal Gland and the SkinHormone Research in Paediatrics, 2000
- Daytime sleepiness in Parkinson’s diseaseJournal of Sleep Research, 2000
- A review of normal sleep and its disturbances in Parkinson’s diseaseParkinsonism & Related Disorders, 1999
- L-Dopa-Induced SedationClinical Neuropharmacology, 1999
- Effects of Age on Sleep Apnea in MenAmerican Journal of Respiratory and Critical Care Medicine, 1998
- The Occurrence of Sleep-Disordered Breathing among Middle-Aged AdultsNew England Journal of Medicine, 1993
- Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases.Journal of Neurology, Neurosurgery & Psychiatry, 1992
- Involvement of Upper-Airway Muscles in Extrapyramidal DisordersNew England Journal of Medicine, 1984
- “Mini-mental state”: A practical method for grading the cognitive state of patients for the clinicianJournal of Psychiatric Research, 1975