Biochemical and Histopathological Evidences for Beneficial Effects ofSatureja Khuzestanica JamzadEssential Oil on the Mouse Model of Inflammatory Bowel Diseases
- 1 January 2006
- journal article
- research article
- Published by Taylor & Francis Ltd in Toxicology Mechanisms and Methods
- Vol. 16 (7), 365-372
- https://doi.org/10.1080/15376520600620125
Abstract
The essential oil from Satureja Khuzestanica Jamzad (SKEO), an endemic plant from Iran, was evaluated for its activity against inflammatory bowel disease (IBD). SKEO was examined on the experimental mouse model of inflammatory bowel disease, which is acetic acid-induced colitis. Prednisolone was used as the standard drug for comparison. Biochemical, macroscopic, and microscopic examinations of colon were performed. Lipid peroxidation significantly increased in acetic acid-treated mice in comparison to the normal group (4.88 vs. 3.02 μmol/g) and was significantly restored by SKEO (500, 1000, 1500 ppm) and prednisolone treatment. The mean percentage of decreases of lipid peroxidation in SKEO (500, 1000, 1500 ppm)- and prednisolone-treated groups were 10.5, 28.5, 42.85, and 33.33 of control, respectively. The myeloperoxidase activity significantly increased in acetic acid-treated mice in comparison to the normal group (4.1 vs. 0.8 U/g) and significantly restored in SKEO (1000 and 1500 ppm)- and prednisolone-treated groups. The mean percentage of decreases of myeloperoxidase activity in SKEO (1000 and 1500 ppm)- and prednisolone-treated groups were 24.56, 50, and 52.63 of control, respectively. SKEO (1000 and 1500 ppm)- and prednisolone-treated groups showed significantly lower score values of macroscopic and microscopic characters when compared to the acetic acid-treated group. The beneficial effect of SKEO (1500 ppm) was comparable to that of prednisolone. Known antioxidant, antimicrobial, antiinflammatory, and antispasmodic potentials of Satureja Khuzestanica may be the mechanisms by which this plant protects animals against experimentally induced IBD. Proper clinical investigation should be carried out to confirm the activity in human disease.Keywords
This publication has 33 references indexed in Scilit:
- Reduction of diabetes-induced oxidative stress by phosphodiesterase inhibitors in ratsComparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 2005
- Composition of the essential oils of wild and cultivated Satureja khuzistanica Jamzad from IranFlavour and Fragrance Journal, 2004
- Essential Oil ofSatureja khuzistanicaJamzadJournal of Essential Oil Research, 2000
- Antiviral activity of Bolivian plant extractsGeneral Pharmacology: The Vascular System, 1999
- Anti-HIV-1 Activity of Herbs in Labiatae.Biological & Pharmaceutical Bulletin, 1998
- Experimental models of inflammatory bowel diseaseGastroenterology, 1995
- Oxidants and free radicals in inflammatory bowel diseaseThe Lancet, 1994
- Serum lipid peroxide in cerebrovascular disorders determined by a new colorimetric methodClinica Chimica Acta; International Journal of Clinical Chemistry, 1978
- Experimental ColitisDigestion, 1976
- A TAXONOMIC STUDY OF LABIATAE AND RELATED GENERANew Phytologist, 1970