Biocatalytic induction of supramolecular order
- 10 October 2010
- journal article
- Published by Springer Science and Business Media LLC in Nature Chemistry
- Vol. 2 (12), 1089-1094
- https://doi.org/10.1038/nchem.861
Abstract
Supramolecular gels, which demonstrate tunable functionalities, have attracted much interest in a range of areas, including healthcare, environmental protection and energy-related technologies. Preparing these materials in a reliable manner is challenging, with an increased level of kinetic defects observed at higher self-assembly rates. Here, by combining biocatalysis and molecular self-assembly, we have shown the ability to more quickly access higher-ordered structures. By simply increasing enzyme concentration, supramolecular order expressed at molecular, nano- and micro-levels is dramatically enhanced, and, importantly, the gelator concentrations remain identical. Amphiphile molecules were prepared by attaching an aromatic moiety to a dipeptide backbone capped with a methyl ester. Their self-assembly was induced by an enzyme that hydrolysed the ester. Different enzyme concentrations altered the catalytic activity and size of the enzyme clusters, affecting their mobility. This allowed structurally diverse materials that represent local minima in the free energy landscape to be accessed based on a single gelator structure.Keywords
This publication has 33 references indexed in Scilit:
- Mechanosensitive Self-Replication Driven by Self-OrganizationScience, 2010
- Spontaneous and X-ray–Triggered Crystallization at Long Range in Self-Assembling Filament NetworksScience, 2010
- High-water-content mouldable hydrogels by mixing clay and a dendritic molecular binderNature, 2010
- Anion-tuning of supramolecular gel propertiesNature Chemistry, 2009
- High‐Tech Applications of Self‐Assembling Supramolecular Nanostructured Gel‐Phase Materials: From Regenerative Medicine to Electronic DevicesAngewandte Chemie-International Edition, 2008
- Self-Assembly of Large and Small Molecules into Hierarchically Ordered Sacs and MembranesScience, 2008
- Probing the Solvent-Assisted Nucleation Pathway in Chemical Self-AssemblyScience, 2006
- Water Gelation by Small Organic MoleculesChemical Reviews, 2004
- Semi-wet peptide/protein array using supramolecular hydrogelNature Materials, 2003
- Beyond molecules: Self-assembly of mesoscopic and macroscopic componentsProceedings of the National Academy of Sciences of the United States of America, 2002