A Multicenter Investigation of Fixed-Dose Fluoxetine in the Treatment of Obsessive-compulsive Disorder
- 1 July 1994
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of General Psychiatry
- Vol. 51 (7), 559-567
- https://doi.org/10.1001/archpsyc.1994.03950070051010
Abstract
Objectives: To determine the effectiveness of fluoxetine hydrochloride at fixed doses of 20 mg/d, 40 mg/d, and 60 mg/d in patients with obsessive-compulsive disorder (OCD) and to evaluate its safety. Methods: Fixed-dose fluoxetine hydrochloride (20 mg/d, 40 mg/d, 60 mg/d) was compared with placebo in two randomized, double-blind, parallel, 13-week trials of identical design in 355 outpatients with OCD aged 15 to 70 years (DSM-III-R criteria; 1 year's duration or longer; depression secondary if present). Results: Fluoxetine (all doses) was significantly (P±001) superior to placebo on the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) total score (mean baseline-to-end—point decrease, 4.6,5.5, and 6.5 vs 0.9, respectively, studies pooled) and other efficacy measures (P±01). A trend suggesting greater efficacy at 60 mg/d was observed. Most patients (79.2%) completed the study. Eight adverse events were statistically significantly more frequent with fluoxetine and one, with placebo. For some events, incidence tended to increase with increasing dosage; however, few patients discontinued treatment for any single event. Conclusion: Fluoxetine was associated with a statistically significant reduction in OCD severity, including time engaged in obsessional and/or compulsive behaviors. Adverse events infrequently led to study discontinuation.Keywords
This publication has 23 references indexed in Scilit:
- Clomipramine in the Treatment of Patients With Obsessive-Compulsive DisorderArchives of General Psychiatry, 1991
- Specificity of Serotonin Reuptake Inhibitors in the Treatment of Obsessive-Compulsive DisorderArchives of General Psychiatry, 1990
- Fluoxetine in the Long-Term Maintenance Treatment of Obsessive Compulsive DisorderPsychiatric Annals, 1989
- Treatment of Obsessive Compulsive Disorder with ClomipraminePsychiatric Annals, 1989
- The Epidemiology of Obsessive-Compulsive Disorder in Five US CommunitiesArchives of General Psychiatry, 1988
- Biochemical effects of the antidepressant paroxetine, a specific 5-hydroxytryptamine uptake inhibitorPsychopharmacology, 1987
- Fluoxetine in the treatment of obsessive compulsive disorderProgress in Neuro-Psychopharmacology and Biological Psychiatry, 1985
- Double-blind comparative study of clomipramine and amitriptyline in obsessive neurosisProgress in Neuro-Psychopharmacology, 1981
- Clomipramine Treatment of Obsessive-Compulsive DisorderArchives of General Psychiatry, 1980
- Treatment of the Phobic Obsessive- Compulsive Patient With Oxazepam, an Improved Benzodiazepine CompoundPsychosomatics, 1967