AMP-Activated Protein Kinase as a Drug Target
Top Cited Papers
- 1 February 2007
- journal article
- review article
- Published by Annual Reviews in Annual Review of Pharmacology and Toxicology
- Vol. 47 (1), 185-210
- https://doi.org/10.1146/annurev.pharmtox.47.120505.105304
Abstract
The AMP-activated protein kinase (AMPK) system is a regulator of energy balance at both the cellular and whole-body levels that, once activated by low energy status, effects a switch from ATP-consuming anabolic pathways to ATP-producing catabolic pathways. It now appears to be the major target for two existing classes of drug used to treat type 2 diabetes, i.e., the biguanides and thiazolidinediones. However, in both cases these activate AMPK indirectly, and an interesting question concerns whether a drug that directly activated AMPK would retain the therapeutic benefits of the existing drugs while eliminating unwanted side effects. AMPK activators also now have potential as anticancer drugs.Keywords
This publication has 101 references indexed in Scilit:
- Does AMP-activated Protein Kinase Couple Inhibition of Mitochondrial Oxidative Phosphorylation by Hypoxia to Calcium Signaling in O2-sensing Cells?Published by Elsevier BV ,2005
- The CREB coactivator TORC2 is a key regulator of fasting glucose metabolismNature, 2005
- Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contractionThe EMBO Journal, 2005
- AMP-activated protein kinase activators can inhibit the growth of prostate cancer cells by multiple mechanismsBiochemical and Biophysical Research Communications, 2004
- Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinaseNature, 2002
- Cell Cycle Regulation via p53 Phosphorylation by a 5′-AMP Activated Protein Kinase Activator, 5-Aminoimidazole- 4-Carboxamide-1-β- -Ribofuranoside, in a Human Hepatocellular Carcinoma Cell LineBiochemical and Biophysical Research Communications, 2001
- AMP-Activated Protein Kinase Is Activated by the Stimulations of Gq-Coupled ReceptorsBiochemical and Biophysical Research Communications, 2000
- Peutz-Jeghers syndrome is caused by mutations in a novel serine threoninekinaseNature Genetics, 1998
- Role of the AMP-activated protein kinase in the cellular stress responseCurrent Biology, 1994
- Increased Risk of Cancer in the Peutz–Jeghers SyndromeNew England Journal of Medicine, 1987