Left Ventricular Systolic Function and Outcome After In-Hospital Cardiac Arrest
- 8 April 2008
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Circulation
- Vol. 117 (14), 1864-1872
- https://doi.org/10.1161/circulationaha.107.740167
Abstract
Background— The effect of prearrest left ventricular ejection fraction (LVEF) on outcome after cardiac arrest is unknown. Methods and Results— During a 26-month period, Utstein-style data were prospectively collected on 800 consecutive inpatient adult index cardiac arrests in an observational, single-center study at a tertiary cardiac care hospital. Prearrest echocardiograms were performed on 613 patients (77%) at 11±14 days before the cardiac arrest. Outcomes among patients with normal or nearly normal prearrest LVEF (≥45%) were compared with those of patients with moderate or severe dysfunction (LVEF 2 and logistic regression analyses. Survival to discharge was 19% in patients with normal or nearly normal LVEF compared with 8% in those with moderate or severe dysfunction (adjusted odds ratio, 4.8; 95% confidence interval, 2.3 to 9.9; P P =0.468) or 24-hour survival (39% versus 36%; P =0.550). Postarrest echocardiograms were performed on 84 patients within 72 hours after the index cardiac arrest; the LVEF decreased 25% in those with normal or nearly normal prearrest LVEF (60±9% to 45±14%; P P P Conclusions— Moderate and severe prearrest left ventricular systolic dysfunction was associated with substantially lower rates of survival to hospital discharge compared with normal or nearly normal function.Keywords
This publication has 25 references indexed in Scilit:
- Predictors of Mortality in Chronic Chagas DiseaseCirculation, 2007
- Gender Modifies the Influence of Age on Outcome After Successfully Resuscitated Cardiac ArrestMedicine, 2006
- Epinephrine Increases Mortality after Brief Asphyxial Cardiac Arrest in an In Vivo Rat ModelAnesthesia & Analgesia, 2006
- Recommendations for Chamber Quantification: A Report from the American Society of Echocardiography’s Guidelines and Standards Committee and the Chamber Quantification Writing Group, Developed in Conjunction with the European Association of Echocardiography, a Branch of the European Society of CardiologyJournal of the American Society of Echocardiography, 2005
- A predictive model for survival after in-hospital cardiopulmonary arrestResuscitation, 2004
- A randomized, blinded trial of high-dose epinephrine versus standard-dose epinephrine in a swine model of pediatric asphyxial cardiac arrestCritical Care Medicine, 1996
- Myocardial dysfunction after resuscitation from cardiac arrest: An example of global myocardial stunningJournal of the American College of Cardiology, 1996
- The natural history and spectrum of idiopathic dilated cardiomyopathy, including HIV and peripartum cardiomyopathyCurrent Opinion in Cardiology, 1995
- Phenylephrine plus propranolol improves the balance between myocardial oxygen supply and demand during experimental cardiopulmonary resuscitationAmerican Heart Journal, 1994
- High-dose epinephrine results in greater early mortality after resuscitation from prolonged cardiac arrest in pigsCritical Care Medicine, 1994