Agmatine and Imidazoline Receptors: Their Role in Opioid Analgesia, Tolerance and Dependence
- 25 July 2007
- journal article
- review article
- Published by Springer Science and Business Media LLC in Cellular and Molecular Neurobiology
- Vol. 28 (5), 629-641
- https://doi.org/10.1007/s10571-007-9164-y
Abstract
Agmatine is an endogenous amine that is synthesized following the decarboxylation of L-arginine by arginine decarboxylase. Agmatine exists in mammalian brain and has been proposed as a neurotransmitter and/or neurotransmodulator. Agmatine binds to several targets and is considered as an endogenous ligand for imidazoline receptors. This review, mainly based on our research work in the past decade, focused on the modulations by agmatine action on imidazoline receptors to opioid analgesia, tolerance and dependence, and its possible neurochemical mechanisms. We went on to propose that agmatine and imidazoline receptors constitute a novel system of modulating opioid functions.Keywords
This publication has 53 references indexed in Scilit:
- Agmatine: Biological role and therapeutic potentials in morphine analgesia and dependenceThe AAPS Journal, 2006
- I1 imidazoline receptor-mediated effects on apoptotic processes in PC12 cellsCell Death & Differentiation, 2004
- Cell Signaling by Imidazoline‐1 Receptor Candidate, IRAS, and the Nischarin HomologueAnnals of the New York Academy of Sciences, 2003
- IRAS, the human homologue of Nischarin, prolongs survival of transfected PC12 cellsCell Death & Differentiation, 2003
- Insulin Receptor Substrate 4 Associates with the Protein IRASPublished by Elsevier BV ,2002
- Imidazoline Receptor Antisera‐Selected cDNA Clone and mRNA DistributionaAnnals of the New York Academy of Sciences, 1999
- INHIBITORY EFFECT OF AGMATINE ON NALOXONE-PRECIPITATED ABSTINENCE SYNDROME IN MORPHINE DEPENDENT RATSLife Sciences, 1997
- Regulation of Electrolyte Transport in Rabbit Tracheal Epithelial Cells by the I1‐Imidazoline Agonist Moxonidinefn1Annals of the New York Academy of Sciences, 1995
- Agmatine: an Endogenous Clonidine-Displacing Substance in the BrainScience, 1994
- Human brain imidazoline receptors: further characterization with [3H]clonidineEuropean Journal of Pharmacology: Molecular Pharmacology, 1994