Apolipoprotein genotype does not influence MS severity, cognition, or brain atrophy
- 29 September 2009
- journal article
- Published by Ovid Technologies (Wolters Kluwer Health) in Neurology
- Vol. 73 (13), 1018-1025
- https://doi.org/10.1212/wnl.0b013e3181b9c85e
Abstract
Background: The influence of APOE allelic heterogeneity on multiple sclerosis (MS) disease severity has been reported in multiple datasets with conflicting results. Several studies have reported an unfavorable association of APOE ε4 with more severe clinical disease course while, in contrast, APOE ε2 has been associated with a more benign disease course. In this study, we examine the influence of heterogeneity of the APOE gene on disease severity in a large, Australian, population-based MS cohort.Keywords
This publication has 38 references indexed in Scilit:
- APOE ε4 allele is associated with cognitive impairment in patients with multiple sclerosisNeurology, 2008
- An extremes of outcome strategy provides evidence that multiple sclerosis severity is determined by alleles at the HLA-DRB1 locusProceedings of the National Academy of Sciences of the United States of America, 2007
- Regulatory region single nucleotide polymorphisms of the apolipoprotein E gene and the rate of cognitive decline in Alzheimer's diseaseHuman Molecular Genetics, 2007
- APOE genotypes in African American female multiple sclerosis patientsNeuroscience Letters, 2007
- Allelic association of sequence variants in the herpes virus entry mediator-B gene (PVRL2) with the severity of multiple sclerosisGenes & Immunity, 2006
- Accelerated evolution of brain atrophy and “black holes” in MS patients with APOE‐ε4Annals of Neurology, 2004
- Neuroplasticity in Alzheimer's diseaseJournal of Neuroscience Research, 2002
- Polymorphisms of apolipoprotein E; outcome and susceptibility in multiple sclerosisMultiple Sclerosis Journal, 2000
- Allelic polymorphisms in the transcriptional regulatory region of apolipoprotein E geneFEBS Letters, 1998
- Rating neurologic impairment in multiple sclerosisNeurology, 1983