Review of studies of child and adolescent offspring of bipolar parents
- 1 December 2001
- journal article
- review article
- Published by Wiley in Bipolar Disorders
- Vol. 3 (6), 325-334
- https://doi.org/10.1034/j.1399-5618.2001.30607.x
Abstract
Objective: The authors reviewed studies of child and adolescent offspring of bipolar (BP) parents. Findings from these studies are critically discussed with respect to methodological issues that can inform future designs. Methods: A Medline search was performed to identify studies that examined child and adolescent offspring of BP parents. Publications were excluded if they did not separate offspring of BP parents from offspring of major depressive disorder or schizoaffective parents (‘affective offspring’) or did not separately analyze data from child‐ and adolescent‐age versus adult offspring. Results: Seventeen studies fit these review criteria. Rates of mood disorders in child and adolescent offspring of BP parents ranged from 5 to 67% compared with rates in offspring of healthy volunteers of 0–38%. Rates of non‐mood disordered psychopathology ranged from 5 to 52% in offspring of BP parents and from 0 to 25% in offspring of healthy volunteers. Rates of mood disorders and of other psychopathology were increased in offspring of BP parents compared with offspring of healthy volunteers in all of the eight studies that included a comparison group of offspring of healthy volunteers. Conclusions: Studies suggest that children (≤21 years) of BP parents are at increased risk for developing mood and other disorders (e.g., disruptive, anxiety). Therefore, additional investigations are clearly warranted. In the context of current research on diagnosis, assessment, longitudinal course and comorbidity of childhood mania, the following suggestions for the design of future studies should be considered: 1) Phenotypic specification of bipolar manifestations (e.g., BP‐I, BP‐II, BP‐NOS) in child/adolescent offspring and in bipolar parents themselves. 2) Control groups that are pediatric‐age relevant and thus include attention‐deficit hyperactivity disorder. 3) Assessments that include items for prepubertal mania and for onsets and offsets of all occurrences of symptoms and of environmental factors (e.g., life events) in offspring and in parents so that trajectories of overlap and sequence between child and parental mania can be investigated. 4) These detailed onsets and offsets of symptoms are also necessary to investigate prodromal manifestations of mania in the offspring. 5) Unaffected offspring present a unique opportunity to study pre‐ and postmorbid cognitive and physiological endophenotypes and structural and functional brain abnormalities. Findings from offspring studies will be crucial to inform research on the development of early intervention and prevention strategies.Keywords
This publication has 51 references indexed in Scilit:
- One-Year Recovery and Relapse Rates of Children With a Prepubertal and Early Adolescent Bipolar Disorder PhenotypeAmerican Journal of Psychiatry, 2001
- Six-Month Stability and Outcome of a Prepubertal and Early Adolescent Bipolar Disorder PhenotypeJournal of Child and Adolescent Psychopharmacology, 2000
- Use of Self-Ratings in the Assessment of Symptoms of Attention Deficit Hyperactivity Disorder in AdultsAmerican Journal of Psychiatry, 2000
- Bipolar II disorder: A progress reportJournal of Affective Disorders, 1996
- Complex and rapid-cycling in bipolar children and adolescents: a preliminary studyJournal of Affective Disorders, 1995
- Protective and resource factors in highand low-risk children: A comparison of children with unipolar, bipolar, medically ill, and normal mothersDevelopment and Psychopathology, 1993
- Psychopathology in children aged 10–17 of bipolar parents: Psychopathology rate and correlates of the severity of the psychopathologyJournal of Affective Disorders, 1989
- Diagnoses in school-age children of bipolar affective disorder patients and normal controlsJournal of Affective Disorders, 1985
- Cyclothymia in the adolescent offspring of parents with bipolar affective disorder.Journal of Abnormal Psychology, 1985
- Speech competence of children vulnerable to psychopathologyJournal of Abnormal Child Psychology, 1982