Hyperthermia and fatigue
- 1 March 2008
- journal article
- review article
- Published by American Physiological Society in Journal of Applied Physiology
- Vol. 104 (3), 871-878
- https://doi.org/10.1152/japplphysiol.00910.2007
Abstract
The present review addresses mechanisms of importance for hyperthermia-induced fatigue during short intense activities and prolonged exercise in the heat. Inferior performance during physical activities with intensities that elicit maximal oxygen uptake is to a large extent related to perturbation of the cardiovascular function, which eventually reduces arterial oxygen delivery to the exercising muscles. Accordingly, aerobic energy turnover is impaired and anaerobic metabolism provokes peripheral fatigue. In contrast, metabolic disturbances of muscle homeostasis are less important during prolonged exercise in the heat, because increased oxygen extraction compensates for the reduction in systemic blood flow. The decrease in endurance seems to involve changes in the function of the central nervous system (CNS) that lead to fatigue. The CNS fatigue appears to be influenced by neurotransmitter activity of the dopaminergic system, but may primarily relate to inhibitory signals from the hypothalamus arising secondary to an increase in brain temperature. Fatigue is an integrated phenomenon, and psychological factors, including the anticipation of fatigue, should not be neglected and the interaction between central and peripheral physiological factors also needs to be considered.Keywords
This publication has 76 references indexed in Scilit:
- Arterial oxygenation influences central motor output and exercise performance via effects on peripheral locomotor muscle fatigue in humansThe Journal of Physiology, 2006
- Responses to exercise in the heat related to measures of hypothalamic serotonergic and dopaminergic functionEuropean Journal of Applied Physiology, 2003
- Relation of heart rate to percentV˙o 2 peak during submaximal exercise in the heatJournal of Applied Physiology, 2003
- Amino acids and central fatigueAmino Acids, 2001
- Heat acclimation, aerobic fitness, and hydration effects on tolerance during uncompensable heat stress.Journal of Applied Physiology, 1998
- Hyperthermia increases cerebral metabolic rate and blood flow in neonatal pigsAmerican Journal of Physiology-Heart and Circulatory Physiology, 1988
- Effects of brain and trunk temperatures on exercise performance in goatsPflügers Archiv - European Journal of Physiology, 1986
- Influence of diuretic-induced dehydration on competitive running performanceMedicine & Science in Sports & Exercise, 1985
- Temperature, skeletal muscle mitochondrial functions, and oxygen debtAmerican Journal of Physiology-Legacy Content, 1971
- Body Temperature and Capacity for WorkActa Physiologica Scandinavica, 1945