Residential Radon and Risk of Lung Cancer
Top Cited Papers
- 1 March 2005
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Epidemiology
- Vol. 16 (2), 137-145
- https://doi.org/10.1097/01.ede.0000152522.80261.e3
Abstract
Background: Underground miners exposed to high levels of radon have an excess risk of lung cancer. Residential exposure to radon is at much lower levels, and the risk of lung cancer with residential exposure is less clear. We conducted a systematic analysis of pooled data from all North American residential radon studies. Methods: The pooling project included original data from 7 North American case–control studies, all of which used long-term α-track detectors to assess residential radon concentrations. A total of 3662 cases and 4966 controls were retained for the analysis. We used conditional likelihood regression to estimate the excess risk of lung cancer. Results: Odds ratios (ORs) for lung cancer increased with residential radon concentration. The estimated OR after exposure to radon at a concentration of 100 Bq/m3 in the exposure time window 5 to 30 years before the index date was 1.11 (95% confidence interval = 1.00–1.28). This estimate is compatible with the estimate of 1.12 (1.02–1.25) predicted by downward extrapolation of the miner data. There was no evidence of heterogeneity of radon effects across studies. There was no apparent heterogeneity in the association by sex, educational level, type of respondent (proxy or self), or cigarette smoking, although there was some evidence of a decreasing radon-associated lung cancer risk with age. Analyses restricted to subsets of the data with presumed more accurate radon dosimetry resulted in increased estimates of risk. Conclusions: These results provide direct evidence of an association between residential radon and lung cancer risk, a finding predicted using miner data and consistent with results from animal and in vitro studies.Keywords
This publication has 34 references indexed in Scilit:
- Do low dose-rate bystander effects influence domestic radon risks?International Journal of Radiation Biology, 2002
- RE: "RESIDENTIAL RADON GAS EXPOSURE AND LUNG CANCER: THE IOWA RADON LUNG CANCER STUDY"American Journal of Epidemiology, 2000
- Residential Radon Gas Exposure and Lung Cancer: The Iowa Radon Lung Cancer StudyAmerican Journal of Epidemiology, 2000
- Characterization of Uncertainty and Variability in Residential Radon Cancer RisksAnnals of the New York Academy of Sciences, 1999
- Residential radon exposure and risk of lung cancer in Missouri.American Journal of Public Health, 1999
- The oncogenic transforming potential of the passage of single α particles through mammalian cell nucleiProceedings of the National Academy of Sciences of the United States of America, 1999
- Lung Cancer Risk From Residential Radon: Meta-analysis of Eight Epidemiologic StudiesJNCI Journal of the National Cancer Institute, 1997
- Toward a more realistic appraisal of the lung cancer risk from radon: the effects of residential mobility.American Journal of Public Health, 1996
- THE AUTHORS REPLYAmerican Journal of Epidemiology, 1995
- Randomized Recruitment in Case-Control StudiesAmerican Journal of Epidemiology, 1991