The Tissue-Type Plasminogen Activator Story
- 1 August 2009
- journal article
- review article
- Published by Ovid Technologies (Wolters Kluwer Health) in Arteriosclerosis, Thrombosis, and Vascular Biology
- Vol. 29 (8), 1151-1155
- https://doi.org/10.1161/atvbaha.108.179655
Abstract
Milestones in the development of tissue-type plasminogen activator (t-PA) as a fibrin-specific thrombolytic agent include: purification of human t-PA from the culture fluid of the Bowes melanoma cell line, elucidation of the molecular basis of fibrin-specific plasminogen activation, first experimental animal models of thrombosis, first patient (renal allograft) treated with melanoma t-PA, pilot studies in patients with acute myocardial infarction, cloning and expression of recombinant t-PA providing sufficient amounts for large scale clinical use, and demonstration of its therapeutic benefit in large multicenter clinical trials.Keywords
This publication has 20 references indexed in Scilit:
- Thrombolytic agentsThrombosis and Haemostasis, 2005
- An International Randomized Trial Comparing Four Thrombolytic Strategies for Acute Myocardial InfarctionThe New England Journal of Medicine, 1993
- Improved thrombolysis with a modified dose regimen of recombinant tissue-type plasminogen activatorJournal of the American College of Cardiology, 1989
- Coronary thrombolysis and infarct size reduction after intravenous infusion of recombinant tissue-type plasminogen activator in nonhuman primates.JCI Insight, 1985
- Coronary Thrombolysis with Tissue-Type Plasminogen Activator in Patients with Evolving Myocardial InfarctionThe New England Journal of Medicine, 1984
- Clot-Selective Coronary Thrombolysis with Tissue-Type Plasminogen ActivatorScience, 1983
- Cloning and expression of human tissue-type plasminogen activator cDNA in E. coliNature, 1983
- Thrombolysis by human tissue plasminogen activator and urokinase in rabbits with experimental pulmonary embolusNature, 1981
- Molecular mechanism of physiological fibrinolysisNature, 1978
- Identification and Some Properties of a New Fast‐Reacting Plasmin Inhibitor in Human PlasmaJBIC Journal of Biological Inorganic Chemistry, 1976