Bronchial Artery Infusion of Mitomycin-C in Advanced Bronchogenic Carcinoma
Open Access
- 1 January 1978
- journal article
- research article
- Published by Informa UK Limited in Acta Radiologica: Oncology, Radiation, Physics, Biology
- Vol. 17 (6), 449-462
- https://doi.org/10.3109/02841867809128176
Abstract
Bronchial angiography was performed in 17 patients with advanced non-oat cell bronchogenic carcinoma. The patients were treated 1 to 5 times with infusions of 10 mg of mitomycin-C (MMC) into the tumor-feeding bronchial artery. All but 2 patients received in addition small doses of vincristine (intravenously) and bleomycin (intramuscularly) or only bleomycin to potentiate the effect of MMC. No major side effects occurred and the systemic toxicity was insignificant. An objective tumor reponse was encountered in 11/17 patients. Intraarterial chemotherapy is strictly local and therefore effective especially in patients with limited or locally advanced disease. In patients with more extensive disease an adjunctive therapy of a more regional or systemic modality must be given.Keywords
This publication has 17 references indexed in Scilit:
- Preoperative Infusion of Mitomycin-C in the Bronchial Artery in Squamous Cell Carcinoma of the LungActa Radiologica. Diagnosis, 1978
- Combination chemotherapy of bronchogenic carcinoma I. Non-oat cellCancer Treatment Reviews, 1977
- Combination chemotherapy of advanced lung cancer.A randomized trialCancer, 1976
- Unresectable squamous cell carcinoma of the lung and its management by combined bleomycin and radiotherapy.A clinical study of the enhanced resultsCancer, 1976
- Bacon (bleomycin, adriamycin, CCNU, oncovin and nitrogen mustard) in squamous lung cancer. Experience in fifty patientsCancer, 1976
- COMB (cyclophosphamide, oncovin, methyl-ccnu, and bleomycin): A four-drug combination in solid tumorsCancer, 1975
- Selective Bronchial and Intercostal ArteriographyPublished by Springer Science and Business Media LLC ,1970
- Selective Arteriography of Arteriovenous Aneurysms of Spinal CordRadiology, 1967
- Transverse Myelitis Following Selective Bronchial ArteriographyRadiology, 1965
- Selective Bronchial ArteriographyRadiology, 1965