The role of secretory antibodies in infection immunity
- 9 August 2010
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature Reviews Microbiology
- Vol. 8 (9), 656-667
- https://doi.org/10.1038/nrmicro2384
Abstract
The mucosal secretory immune system provides an important primary defence against disease, as studies of humans with mucosal humoral immunodeficiencies suggest that the absence of secretory immunoglobulin A leads to an increase in mucosal infections. However, the infection risks posed do not seem to provide the evolutionary drive to retain constitutive secretion of often 'hard won' protein, suggesting that secretory antibodies may have some other important function (or functions). This Review examines the evidence that secretory antibodies provide an important defence against infection in specific animal models and explores complementary explanations for the evolution of the secretory immune system.Keywords
This publication has 149 references indexed in Scilit:
- A dominant, coordinated T regulatory cell-IgA response to the intestinal microbiotaProceedings of the National Academy of Sciences of the United States of America, 2009
- Induction of Intestinal Th17 Cells by Segmented Filamentous BacteriaCell, 2009
- Excretion of Human Immunodeficiency Virus Type 1 through Polarized Epithelium by Immunoglobulin AJournal of Virology, 2008
- The Biology of Intestinal Immunoglobulin A ResponsesImmunity, 2008
- Entry Route of Salmonella typhimurium Directs the Type of Induced Immune ResponseImmunity, 2007
- Rotavirus Anti-VP6 Secretory Immunoglobulin A Contributes to Protection via Intracellular Neutralization but Not via Immune ExclusionJournal of Virology, 2006
- Regulation of B1 cell migration by signals through Toll-like receptorsThe Journal of Experimental Medicine, 2006
- Contribution of polymeric immunoglobulin receptor to regulation of intestinal inflammation in dextran sulfate sodium‐induced colitisJournal of Gastroenterology and Hepatology, 2006
- DCs induce CD40-independent immunoglobulin class switching through BLyS and APRILNature Immunology, 2002
- Molecular cloning of the human transmembrane secretory component (poly-Ig receptor) and its mRNA expression in human tissuesBiochemical and Biophysical Research Communications, 1989