Post-translational modifications of microtubules
Open Access
- 15 October 2010
- journal article
- review article
- Published by The Company of Biologists in Journal of Cell Science
- Vol. 123 (20), 3447-3455
- https://doi.org/10.1242/jcs.063727
Abstract
Microtubules – polymers of tubulin – perform essential functions, including regulation of cell shape, intracellular transport and cell motility. How microtubules are adapted to perform multiple diverse functions is not well understood. Post-translational modifications of tubulin subunits diversify the outer and luminal surfaces of microtubules and provide a potential mechanism for their functional specialization. Recent identification of a number of tubulin-modifying and -demodifying enzymes has revealed key roles of tubulin modifications in the regulation of motors and factors that affect the organization and dynamics of microtubules.Keywords
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