p63 Is a Promising Marker in the Diagnosis of Unusual Skin Cancer
Open Access
- 17 November 2019
- journal article
- review article
- Published by MDPI AG in International Journal of Molecular Sciences
- Vol. 20 (22), 5781
- https://doi.org/10.3390/ijms20225781
Abstract
Skin cancer is the most common type of cancer worldwide. Ozone depletion and climate changes might cause a further increase in the incidence rate in the future. Although the early detection of skin cancer enables it to be treated successfully, some tumours can evolve and become more aggressive, especially in the case of melanoma. Therefore, good diagnostic and prognostic markers are needed to ensure correct detection and treatment. Transcription factor p63, a member of the p53 family of proteins, plays an essential role in the development of stratified epithelia such as skin. In this paper, we conduct a comprehensive review of p63 expression in different types of skin cancer and discuss its possible use in the diagnosis and prognosis of cutaneous tumours.Keywords
Funding Information
- Associazione Italiana per la Ricerca sul Cancro (IG22206)
This publication has 129 references indexed in Scilit:
- An integrated encyclopedia of DNA elements in the human genomeNature, 2012
- ZNF750 Is a p63 Target Gene that Induces KLF4 to Drive Terminal Epidermal DifferentiationDevelopmental Cell, 2012
- iASPP/p63 autoregulatory feedback loop is required for the homeostasis of stratified epitheliaThe EMBO Journal, 2011
- Identifying the cellular origin of squamous skin tumorsProceedings of the National Academy of Sciences of the United States of America, 2011
- Hdac1 and Hdac2 Act Redundantly to Control p63 and p53 Functions in Epidermal Progenitor CellsDevelopmental Cell, 2010
- The C-terminus of p63 contains multiple regulatory elements with different functionsCell Death & Disease, 2010
- The first 30 years of p53: growing ever more complexNature Reviews Cancer, 2009
- ΔNp63 regulates thymic development through enhanced expression of FgfR2 and Jag2Proceedings of the National Academy of Sciences of the United States of America, 2007
- Structural evolution of C-terminal domains in the p53 familyThe EMBO Journal, 2007
- p63 induces key target genes required for epidermal morphogenesisProceedings of the National Academy of Sciences of the United States of America, 2007